Hiroyoshi Nishikawa from 475 Main St, New York, NY 10044, Phone: 2129355577

Methods For Stimulating An Immune Response Using Bacterial Antigen Delivery System
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US Patent:

20090324651, Dec 31, 2009
Filed:

Oct 3, 2006
Appl. No.:

12/083188
Inventors:

Lloyd J. Old - New York NY, US
Gerd Ritter - New York NY, US
Hiroyoshi Nishikawa - New York NY, US
Sacha Gnjatic - New York NY, US
Jorge E. Galan - New Haven CT, US
International Classification:

A61K 39/00
A61K 35/74
C12N 5/00
A61K 35/12
C12N 1/21
A61P 37/04
US Classification:

4242771, 424 934, 435375, 435325, 424 9371, 4352523
Abstract:

The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.

Hiroyoshi Nishikawa