Hoc T Nguyen

US Patent:

51927438, Mar 9, 1993

Filed:

Jan 16, 1992

Appl. No.:

7/821206

Inventors:

Chung C. Hsu - Los Altos Hills CA
Hoc M. Nguyen - San Francisco CA
Sylvia S. Wu - San Ramon CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 3702

US Classification:

514 8

Abstract:

A formulation for proteins is provided that comprises a lyophilized mixture of a protein, a water-soluble etherified cellulose in an amount that upon reconstitution of the formulation will be sufficient to form a gel, and an excipient to facilitate rehydration of the gel and to maintain protein integrity during storage of the lyophilized gel product. When reconstituted to a gel, this formulation can be applied, for example, to tissue in need of treatment.

US Patent:

46421173, Feb 10, 1987

Filed:

Mar 22, 1985

Appl. No.:

6/715098

Inventors:

Hoc M. Nguyen - Sunnyvale CA
George H. Chu - Sunnyvale CA

Assignee:

Collagen Corporation - Palo Alto CA

International Classification:

A61F 210
A61F 228
A61K 3712

US Classification:

623 11

Abstract:

An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The mechanically sheared fibers may be further crosslinked to improve implant characteristics.