Homer D Pantua

US Patent:

20070178120, Aug 2, 2007

Filed:

Aug 2, 2006

Appl. No.:

11/497888

Inventors:

Trudy Morrison - Northborough MA, US
Homer Pantua - Worcester MA, US

International Classification:

A61K 39/17
C12N 7/02
C12N 5/06
C12N 15/86

US Classification:

424214100, 435456000, 977802000, 435239000, 435349000

Abstract:

The present invention discloses the method of making and using a novel, non-infective, paramyxovirus vaccine. Paramyxovirus structural proteins within a virus-like particle (VLP) comprise one example of such a vaccine. It is observed that the presence of matrix protein, alone, is sufficient and necessary to provide an effective VLP release. Co-expression of four paramyxovirus structural proteins, however, result in the release of non-infective VLPs with densities and efficiencies of release similar to that of infective particles. Representative diseases wherein a VLP vaccine might be useful include, but are not limited to, Newcastle disease, measles, respiratory syncytial virus infection, and parainfluenza 3 virus infection.