Hong Li

US Patent:

6470219, Oct 22, 2002

Filed:

Oct 2, 2000

Appl. No.:

09/678500

Inventors:

Stuart D. Edwards - Portola Valley CA
Peter Edelstein - Woodside CA
Hong Li - San Diego CA

Assignee:

Novasys Medical, Inc. - Newark CA

International Classification:

A61B 1818

US Classification:

607101, 607104, 607138, 606 41

Abstract:

Apparatus for remodeling in the urinary tract of a human female comprising a remodeling device having a shaft with a profile and with proximal and distal extremities. A handle is secured to the proximal extremity of the shaft. A member is mounted on the distal extremity of the shaft. A plurality of needle electrodes are carried by the distal extremity of the shaft and are disposed circumferentially of the shaft. A pusher is carried by the handle for moving the needle electrodes from a retracted position in which they are within the profile of the shaft and an extended position in which they extend sidewise beyond the profile of the shaft. A pump is connected to the handle for supplying a cooling liquid to the distal extremity of the shaft so that it exits from the shaft in the vicinity of the needle electrodes. An RF generator is coupled to the handle and to the needle electrodes for supplying radio frequency energy to the needle electrodes.

US Patent:

6471694, Oct 29, 2002

Filed:

Aug 9, 2000

Appl. No.:

09/635108

Inventors:

Ravikumar V. Kudaravalli - San Diego CA
Hong Li - San Diego CA

Assignee:

CryoGen, Inc. - San Diego CA

International Classification:

A61B 1818

US Classification:

606 21, 606 22

Abstract:

An apparatus and method for automatic operation of a refrigeration system to provide refrigeration power to a catheter for tissue ablation or mapping. The primary refrigeration system can be open loop or closed loop, and a precool loop will typically be closed loop. Equipment and procedures are disclosed for bringing the system to the desired operational state, for controlling the operation by controlling refrigerant flow rate, for performing safety checks, and for achieving safe shutdown.

US Patent:

6537271, Mar 25, 2003

Filed:

Jul 6, 2000

Appl. No.:

09/611240

Inventors:

David R. Murray - Castle Rock CO
Hong Li - San Diego CA

Assignee:

CryoGen, Inc. - San Diego CA

International Classification:

A61B 1818

US Classification:

606 21, 606 23

Abstract:

A method and apparatus for inflating a balloon at a distal portion of an elongated delivery catheter to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant or with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.

US Patent:

6796957, Sep 28, 2004

Filed:

Oct 23, 2001

Appl. No.:

10/004525

Inventors:

Kenneth W. Carpenter - La Jolla CA
Michelle Fourmont - Carlsbad CA
E. Thomas Malphus - La Jolla CA
Kazuo Sasamine - Lemon Grove CA
Hong Li - San Diego CA

Assignee:

Myocardial Therapeutics, Inc. - La Jolla CA

International Classification:

A61M 3100

US Classification:

604 9301, 604154, 604131

Abstract:

The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.

US Patent:

6814730, Nov 9, 2004

Filed:

Sep 23, 2002

Appl. No.:

10/252231

Inventors:

Hong Li - San Diego CA 92130

International Classification:

A61B 1804

US Classification:

606 28, 606 27, 607 96, 607105, 607113

Abstract:

Balloon catheters according to the present invention have surface contours with protrusions and grooves to make non-continuous lesions. There is a heating element inside the balloon. The balloon will be filled with a fluid before ablation to expand the balloon for tissue contact, and to transfer heating energy from the heating element to the tissue in contact with the balloon. Since the balloon surface has contours with grooves and protrusions, the tissue contact will not be continuous along the balloon surfaces, and therefore the ablation on the tissue will not be continuous. The energy transmitter can be ultrasound transducer, electrical resistant heater, and microwave antenna.

US Patent:

7291129, Nov 6, 2007

Filed:

Jul 25, 2002

Appl. No.:

10/207689

Inventors:

Hong Li - San Diego CA, US
Peter S Edelstein - Menlo Park CA, US
John T To - Newark CA, US
Simon W. H. Thomas - Danville CA, US
Benjamin T Nordell - San Mateo CA, US

Assignee:

Novasys Medical Inc. - Newark CA

International Classification:

A61M 5/178

US Classification:

60416401, 60416409

Abstract:

Apparatus and methods are provided for treating female urinary incontinence by injecting a bulking agent at the interface between the mucosal and submucosal layers of the urethral wall. The remodeling device comprises an elongated shaft preferably having means for forming a localized inward protrusion of the urethral wall, and a needle, movable between retracted and deployed positions, for delivering a bulking agent into the urethral wall in the vicinity of the localized inward protrusion to thereby reduce or eliminate symptoms associated with urinary incontinence.

US Patent:

RE40049, Feb 12, 2008

Filed:

Apr 26, 2006

Appl. No.:

11/412250

Inventors:

Hong Li - San Diego CA, US

Assignee:

AMS Research Corporation - Minnetonka MN

International Classification:

F25D 3/00
F25B 9/00
F25B 7/00

US Classification:

62293, 62 6, 62114, 62335, 606 20, 606 22, 606 25

Abstract:

A method and apparatus for using a secondary refrigerant to precool and liquefy a primary refrigerant, then vaporizing and expanding the primary refrigerant to cool a cold tip of a cryosurgical instrument for ablation of biological tissue, such as cardiovascular tissue, in particular endocardiac tissue and tissue inside a cardiac blood vessel. The secondary refrigerant has a critical temperature above the critical temperature of the primary refrigerant, and a cooling temperature below the critical temperature of the primary refrigerant, thereby facilitating the use of the precooling step to provide liquid primary refrigerant in an operating room environment in which the primary refrigerant could not otherwise be provided in the liquid phase.

US Patent:

7401192, Jul 15, 2008

Filed:

Oct 4, 2004

Appl. No.:

10/958724

Inventors:

Christopher John Stakutis - Concord MA, US
Erik Dean Wilkinson - Nashua NH, US
Hong Li - Acton MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 12/00
G06F 13/00
G06F 13/28

US Classification:

711162, 711161, 707203, 707204

Abstract:

Provided are a method, system, and program for replicating a file. A file is copied to a target storage file system stored as a base file. A reference file comprising the copied file is generated at a local storage. An update is applied to the file at the local storage. A delta file is generated indicating differences between the updated file at the local storage and the reference file. A file system command is used to transmit the delta file to the target storage file system store to store in a directory of the target storage file system, wherein the file in the local storage is replicated at the target storage by a combination of the base file and the delta file.