New London VA Outpatient Clinic 4 Shaws Cv STE 101, New London, CT 06320 8604373611 (phone), 8604371801 (fax)
East Haven Counseling & Community Services 595 Thompson Ave, East Haven, CT 06512 2034683297 (phone), 2034683334 (fax)
VA Connecticut Healthcare System Psychiatry 950 Campbell Ave Blg1 Fl7, New Haven, CT 06516 2039325711 (phone), 2039373886 (fax)
Languages:
English Spanish
Description:
Dr. Lin works in East Haven, CT and 2 other locations and specializes in Psychiatry. Dr. Lin is affiliated with VA Connecticut Healthcare System West Haven Campus and Yale-New Haven Childrens Hospital.
Sampathkumar Krishnan - Camarillo CA, US Monica Pallitto - Bellevue WA, US Margaret Ricci - Camarillo CA, US Wenjin Cao - Simi Valley CA, US Hong Lin - Westlake Village CA, US Yong Xie - Thousand Oaks CA, US Samantha Nagle - Dupont WA, US Shon Lee Crampton - Seattle WA, US
The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described.
Concentrated Protein Lyophilates, Methods, And Uses
Sampathkumar Krishnan - Camarillo CA, US Monica Pallitto - Bellevue WA, US Margaret Ricci - Camarillo CA, US Wenjin Cao - Simi Valley CA, US Hong Lin - Westlake Village CA, US Yong Xie - Thousand Oaks CA, US Samantha Nagle - Dupont WA, US Shon Lee Crampton - Seattle WA, US
International Classification:
C07K 19/00 C07K 16/18
US Classification:
530351, 5303891
Abstract:
The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described.
Vaikko P. Allen - Oxnard CA, US Jeremiah M. Lehman - Vancouver WA, US James H. Lenhart - Portland OR, US Hong Lin - Elk Grove CA, US Daniel P. Cobb - Gray ME, US Gregory W. Byrne - West Linn OR, US
International Classification:
C02F 3/32
US Classification:
210602
Abstract:
A stormwater filtration system suitable for treatment of stormwater runoff in a developed environment uses a primary treatment bay that includes a filtration bed with live plant matter. A second treatment bay treats water that exceeds the maximum throughput of the primary bay. A reservoir stores treated runoff to water the plants during dry weather. Removable trays on the surface of the primary filtration bed provide plants suitable for ground cover. Additional bays expand the filtration bed throughput and accommodate extended root systems. A flow control may be provided for the primary treatment bay.