Hongmin Chen

US Patent:

7031354, Apr 18, 2006

Filed:

Feb 11, 2004

Appl. No.:

10/776809

Inventors:

Hsing Cheng - San Jose CA, US
Hongmin Chen - Acton MA, US
Hamid R. Khazaei - Westford MA, US

Assignee:

Optovia Corporation - Action MA

International Classification:

H01S 3/13

US Classification:

372 2902, 372 99

Abstract:

In a stabilized laser system, an output of a desired wavelength is generated. Each of a plurality of n lasers, which, while emitting light and having a preselected portion thereof fed back thereto, causes the fed back portion to be amplified and shifted in wavelength in a first direction which is spaced apart from the center wavelength of the feedback signal. A feedback stabilization arrangement is coupled to output ports of the plurality of n lasers for generating a feedback signal having a wavelength spectrum peaking at a wavelength shifted in an opposite direction to the first direction generated by the lasers in response to the feedback signal so as to provide an output signal at the output of the stabilized laser system having a wavelength spectrum that peaks essentially at the desired wavelength. A reflector is located at a predetermined signal round-trip time delay distance from the feedback stabilization arrangement. The reflector receives the output signal from the feedback stabilization arrangement and passes a first portion thereof therethrough, and reflects a remaining second portion back to the feedback stabilization arrangement as a secondary feedback signal that contributes to each of the plurality of n laser sources being set in a stable coherence collapse mode.

US Patent:

7031355, Apr 18, 2006

Filed:

Feb 11, 2004

Appl. No.:

10/776808

Inventors:

Hamid R. Khazaei - Westford MA, US
Hongmin Chen - Acton MA, US
David Kirk Lewis - Maynard MA, US
Hsing Cheng - San Jose CA, US

Assignee:

Optovia Corporation - Action MA

International Classification:

H01S 3/13
H01S 3/10

US Classification:

372 32, 372 2902, 372 20

Abstract:

In a stabilized laser system, a an output signal is to be generated having a desired central wavelength. At least one laser, which, while emitting light and having a preselected portion thereof fed back thereto, causes the output signal of the laser to be shifted in wavelength in a first direction which is spaced apart from the center wavelength of the fed back signal. A feedback generating arrangement processes a first portion of the output signal from each laser and generates a feedback signal having a spectral response peaking at a wavelength shifted in an opposite direction to the first direction generated by each laser. The feedback signal each laser to provide an output signal at the output of the stabilized laser system having a spectral response that peaks essentially at the desired wavelength.

US Patent:

7169603, Jan 30, 2007

Filed:

Jul 16, 2001

Appl. No.:

09/906206

Inventors:

Mary Lynne Hedley - Lexington MA, US
Robert G. Urban - Lexington MA, US
Nazneen Aziz - Lexington MA, US
Hongmin Chen - Framingham MA, US
Bijan Etemad-Moghadam - Jamaica Plain MA, US
Peng Yin - Newton MA, US

Assignee:

MGI Pharma Biologics, Inc. - Lexington MA

International Classification:

C12N 1/00
C12P 21/02
C07H 21/00

US Classification:

4353201, 435 697, 435 691, 536 231, 536 234, 536 241

Abstract:

The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering α-MSH containing peptides, α-MSH analogs, an DNA encoding α-MSH and α-MSH analogs.

US Patent:

7869473, Jan 11, 2011

Filed:

Mar 21, 2008

Appl. No.:

12/053344

Inventors:

Xiong Ye - Newton MA, US
Hongmin Chen - Waltham MN, US
Yasuhiro Matsui - Woburn MA, US
Daniel Mahgerefteh - Palo Alto CA, US

Assignee:

Finisar Corporation - Sunnyvale CA

International Classification:

H01S 3/10

US Classification:

372 28

Abstract:

A DBR laser, such as a semiconductor DBR laser is disclosed having improved frequency modulation performance. The laser includes a split gain electrode and a tuning electrode. A modulating current encoding a data signal is injected into a first section of the gain electrode whereas a substantially DC bias voltage is imposed on a second section of the gain electrode positioned between the first gain electrode and the tuning electrode. The first and second gain electrodes are electrically isolated from each other and the tuning electrode by a large isolation resistance. In some embodiments, the isolation resistance is generated by forming the electrodes on a P+ layer and removing portions of the P+ layer between adjacent electrodes. Capacitors may couple to one or both of the second gain electrode and the tuning electrode.

US Patent:

8027593, Sep 27, 2011

Filed:

Feb 8, 2008

Appl. No.:

12/028678

Inventors:

Jianying Zhou - Acton MA, US
Xueyan Zheng - Andover MA, US
Kevin J. McCallion - Charlestown MA, US
Daniel Mahgerefteh - Palo Alto MA, US
Hongmin Chen - Waltham MA, US
Guoxi Sun - Woburn MA, US
Parviz Tayebati - Boston MA, US

Assignee:

Finisar Corporation - Sunnyvale CA

International Classification:

H04B 10/12

US Classification:

398193, 398185, 398192, 398194, 398195, 398196, 398197, 398198, 398199

Abstract:

The frequency chirp modulation response of a directly modulated laser is described using a small signal model that depends on slow chirp amplitude s and slow chirp time constant τ. The small signal model can be used to derive an inverse response for designing slow chirp compensation means. Slow chirp compensation means include electrical compensation, optical compensation, or both. Slow chirp electrical compensation can be implemented with an LR filter or other RF circuit coupled to a direct modulation source (e. g. , a laser driver) and the directly modulated laser. Slow chirp optical compensation can be implemented with an optical spectrum reshaper having a rounded top and relatively large slope (e. g. , 1. 5-3 dB/GHz). The inverse response can be designed to under-compensate, to produce a flat response, or to over-compensate.

US Patent:

20050175288, Aug 11, 2005

Filed:

Feb 11, 2004

Appl. No.:

10/776810

Inventors:

Hongmin Chen - Acton MA, US
Hamid Khazaei - Westford MA, US

International Classification:

G02B006/26
G02B006/28

US Classification:

385048000, 385024000

Abstract:

A basic reflector arrangement has first and second power splitters. The first power splitter has first, second, third, and fourth ports where the first port is coupled to a remote signal source for receiving signals therefrom and providing feedback signals thereto. Signals received at each of the first and fourth ports are combined and split into first and second portions for transmission via the second and third ports, respectively, and signals received at the second and third ports are combined and split into first and second portions for transmission via the first and fourth ports, respectively. The second power splitter has first, second, third, and fourth ports, where the second port is coupled to provide an output signal from the reflector arrangement, and the first, third, and fourth ports are coupled to the second, third, and fourth ports, respectively, of the at least one first power splitter. Various components such as transmission filters, filter/multiplexers, and delay lines can be added in paths coupling the first and second power splitters for processing the reflector output and feedback signals.

US Patent:

20050282198, Dec 22, 2005

Filed:

May 3, 2005

Appl. No.:

11/121634

Inventors:

Gordon Duff - Sheffield, GB
Angela Cox - Sheffield, GB
Nicola Camp - Salt Lake City UT, US
Franceso diGiovine - Sheffield, GB
Kenneth Kornman - Newton MA, US
Leon Wilkins - North Andover MA, US
Hongmin Chen - Devens MA, US
John Rogus - North Andover MA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.

US Patent:

20070015257, Jan 18, 2007

Filed:

Jul 21, 2006

Appl. No.:

11/490686

Inventors:

Mary Hedley - Lexington MA, US
Robert Urban - Lexington MA, US
Nazneen Aziz - Lexington MA, US
Hongmin Chen - Framingham MA, US
Bijan Etemad-Moghadam - Jamaica Plain MA, US
Peng Yin - Newton MA, US

International Classification:

A61K 38/22
C07H 21/04
A61K 38/34
C07K 14/68

US Classification:

435069400, 435320100, 435325000, 530399000, 536023500, 514012000

Abstract:

The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering α-MSH containing peptides, α-MSH analogs, an DNA encoding α-MSH and α-MSH analogs.