Howard M Goodman

US Patent:

6355411, Mar 12, 2002

Filed:

Nov 25, 1998

Appl. No.:

09/199637

Inventors:

Frederick Ausubel - Newton MA
Howard M. Goodman - Newton MA
Laurence G. Rahme - Brookline MA
Man-Wah Tan - Somerville MA
Hui Cao - Malden MA
Eliana Drenkard - Cambridge MA
John Tsongalis - Southbridge MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12Q 100

US Classification:

435 4, 530350

Abstract:

Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e. g. , DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

US Patent:

6841722, Jan 11, 2005

Filed:

Apr 7, 2000

Appl. No.:

09/545072

Inventors:

Yun Lin - Somerville MA, US
Lin Sun - West Roxbury MA, US
Long V. Nguyen - Vacaville CA, US
Howard M. Goodman - Newton MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A01H 500
A01H 510
C12H 1529
C12H 1582

US Classification:

800298, 424 932, 4353201, 435419, 4352523, 536 236, 800306

Abstract:

Disclosed is a sse1 gene, which is responsible for protein and oil body biogenesis. The invention further provides methods for using the disclosed gene for modifying the components of plant storage reserve materials.

US Patent:

59258071, Jul 20, 1999

Filed:

Mar 25, 1997

Appl. No.:

8/823986

Inventors:

Hui-Hwa Chiang - Cambridge MA
Howard M. Goodman - Newton Centre MA

Assignee:

General Hospital Corporation - Boston MA

International Classification:

A01H 500
A01H 510
C12N 504
C12N 1529

US Classification:

800298

Abstract:

The invention relates to the DNA and protein encoded by the GA4 locus. This protein is believed to be a member of the family of enzymes involved in the biosynthesis of the gibberellin family (GA) of plant growth hormones which promote various growth and developmental processes in higher plants, such as seed germination, stem elongation, flowering and fruiting. More specifically, the protein encoded by the GA4 locus is an hydroxylase. The invention also relates to vectors containing the DNA and the expression of the protein encoded by the DNA of the invention in a host cell. Additional aspects of the invention are drawn to host cells transformed with the DNA or antisense sequence of the invention, the use of such host cells for the maintenance, or expression or inhibition of expression of the DNA of the invention and to transgenic plants containing DNA of the invention. Finally, the invention also relates to the use of the protein encoded by the GA4 locus to alter aspects of plant growth.

US Patent:

56230540, Apr 22, 1997

Filed:

Jun 23, 1994

Appl. No.:

8/266451

Inventors:

Hong Zhang - Boston MA
Howard M. Goodman - Newton Center MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C07K 14415
C12N 1500

US Classification:

530370

Abstract:

Purified DNA encoding crucifer AFT proteins and chimeric transcriptional activator proteins from such DNA are disclosed. Such proteins are also involved in plant defense mechanisms by interacting with proteins involved in protecting plants from pathogens. The recombinant polypeptides and fragments are useful in methods of modulating plant gene expression.

US Patent:

58637745, Jan 26, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/486569

Inventors:

James Haseloff - Cambridge MA
Andrea Brand - Comberton, GB2
Norbert Perrimon - Brookline MA
Howard M. Goodman - Newton MA

Assignee:

The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C12N 1500
C12N 1585
C12Q 168

US Classification:

4351723

Abstract:

The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.

US Patent:

49753746, Dec 4, 1990

Filed:

Feb 4, 1987

Appl. No.:

7/010612

Inventors:

Howard Goodman - Newton MA
Shiladitya DasSarma - Amherst MA
Edmund Tischer - Palo Alto CA
Theresa K. Peterman - Cambridge MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 1500
C12N 900
C12N 120
C07H 1512

US Classification:

4351723

Abstract:

The invention relates to a mutant glutamine synthetase (GS) enzyme which is resistant to inhibition by herbicidal GS inhibitors, such as phosphinothricin (PPT), genetic sequences coding therefor, plants cells and prokaryotes transformed with the genetic sequences, and herbicidal GS inhibitor-resistant plant cells and plants.

US Patent:

60180978, Jan 25, 2000

Filed:

Apr 11, 1995

Appl. No.:

8/419850

Inventors:

Richard Selden - Camb. MA
Howard Goodman - Newton MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A01K 6700
A01K 67033
C12N 1500
G01N 3300

US Classification:

800 18

Abstract:

A process for producing a transgenic mouse which contains and expresses the human insulin hormone gene. The insulin gene is expressed only in the pancreas of the transgenic mouse and is regulated by glucose, glucagon, or other insulin affectors in a manner which is indistinguishable from that of normal mice. Progeny of the trangenic mice inherit the human insulin gene in a Mendelian manner, with approximately 50% of the mice of each litter expressing the human insulin gene. The weights of the transgenic mice, growth rate, feeding behavior, reproductive capability, and longevity appear indistinguishable from normal mice. The mice are useful for studies of pharmacokinetics of insulin expression and for investigations of possible drug interactions with glucose homeostasis.

US Patent:

58593462, Jan 12, 1999

Filed:

Nov 14, 1996

Appl. No.:

8/748725

Inventors:

Hong Zhang - Boston MA
Howard M. Goodman - Newton Center MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 1529
C12N 1582
C07K 14415
A01H 500

US Classification:

800205

Abstract:

Purified DNA encoding crucifer AFT proteins and chimeric transcriptional activator proteins from such DNA are disclosed. Such proteins are also involved in plant defense mechanisms by interacting with proteins involved in protecting plants from pathogens. The recombinant polypeptides and fragments are useful in methods of modulating plant gene expression.