Howard Craig Zisser

US Patent:

20110313680, Dec 22, 2011

Filed:

Jun 22, 2011

Appl. No.:

13/166806

Inventors:

Eyal Dassau - Goleta CA, US
Howard Zisser - Santa Barbara CA, US
Rebecca A. Harvey - Goleta CA, US

International Classification:

G06F 19/00

US Classification:

702 19

Abstract:

A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent.

US Patent:

20130231642, Sep 5, 2013

Filed:

Apr 2, 2013

Appl. No.:

13/854963

Inventors:

Benyamin Grosman - Northridge CA, US
Eyal Dassau - Goleta CA, US
Lois Jovanovic - Santa Barbara CA, US
Howard Zisser - Santa Barbara CA, US

International Classification:

A61M 31/00

US Classification:

6048901

Abstract:

The disclosure relates to drug delivery and maintaining multiple defined physiological zones using model predictive control.

US Patent:

20110208156, Aug 25, 2011

Filed:

Feb 11, 2011

Appl. No.:

13/026161

Inventors:

Benyamin Grosman - Goleta CA, US
Eyal Dassau - Goleta CA, US
Lois Javanovic - Santa Barbara CA, US
Howard Zisser - Santa Barbara CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
SANSUM DIABETES RESEARCH INSTITUTE - Santa Barbara CA

International Classification:

A61M 5/168

US Classification:

604504, 604 66

Abstract:

A method, computer implemented method and associated apparatus for the management of diabetes is provided.

US Patent:

20160256087, Sep 8, 2016

Filed:

May 7, 2016

Appl. No.:

15/149129

Inventors:

- Oakland CA, US
Rebecca Harvey - Santa Barbara CA, US
Eyal Dassau - Cambridge MA, US
Howard Zisser - Santa Barbara CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 5/145
A61B 5/00
G06F 19/00
A61M 5/172

Abstract:

A glucose rate increase detector (GRID) for use in an artificial pancreas (AP), wherein the GRID detects in a person persistent increases in glucose associated with a meal, and either triggers a meal bolus to blunt meal peak safely, during closed-loop control, or alerts the person to bolus for a meal, during open-loop control.

US Patent:

20160015890, Jan 21, 2016

Filed:

Jun 9, 2015

Appl. No.:

14/734994

Inventors:

- Santa Barbara CA, US
Howard Craig Zisser - Santa Barbara CA, US
Samir Suresh Mitragotri - Santa Barbara CA, US

International Classification:

A61M 5/14
A61M 5/168

Abstract:

Disclosed are systems and methods for variable dose glucagon delivery without the need to manually reconstitute the glucagon. These systems and methods mat be utilized with or without a separate continuous glucose monitor. The variability of the dose may be determined manually by the user, caregiver or responder, or by preprogrammed algorithms utilizing the input from an external sensor such as a continuous glucose monitor.

US Patent:

20150353619, Dec 10, 2015

Filed:

Jun 10, 2015

Appl. No.:

14/735742

Inventors:

- Pasadena CA, US
Seth Lieblich - Pasadena CA, US
Katherine Y. Fang - Pasadena CA, US
Howard C. Zisser - Santa Barbara CA, US

International Classification:

C07K 14/62

Abstract:

In some aspects, the invention relates to an insulin derivative, comprising a cyclic amino acid at position B28 or B29, wherein the cyclic amino acid is not L-proline. In some aspects, the invention relates to a method of making said insulin derivative. In some aspects, the invention relates to a pharmaceutical composition comprising said insulin derivative. In some aspects the invention relates to a method of treating a disease or condition in a subject comprising administering to the subject a composition comprising said insulin derivative.