Howland S Warren from 40 Royal Ave, Cambridge, MA 02138, Phone: 6178764631

Us Patents

Use Of Hmg Fragments As Anti-Inflammatory Agents
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US Patent:

20030060410, Mar 27, 2003
Filed:

May 15, 2002
Appl. No.:

10/147447
Inventors:

Kevin Tracey - Old Greenwich CT, US
Huan Yang - Douglaston NY, US
Howland Warren - Cambridge MA, US
Mitchell Fink - Pittsburgh PA, US
Assignee:

North Shore Long Island Jewish Research Institute - Manhassett NY
International Classification:

A61K038/17
C07K014/435
US Classification:

514/012000, 530/350000
Abstract:

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Use Of Hmgb Fragments As Anti-Inflammatory Agents
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US Patent:

20030144201, Jul 31, 2003
Filed:

Nov 20, 2002
Appl. No.:

10/300072
Inventors:

Kevin Tracey - Old Greenwich CT, US
Huan Yang - Douglaston NY, US
Howland Warren - Cambridge MA, US
Mitchell Fink - Pittsburgh PA, US
Assignee:

North Shore-Long Island Jewish Research Institute - Manhasset NY
International Classification:

A61K038/17
C07K014/47
US Classification:

514/012000, 530/350000
Abstract:

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Method For Preventing Acute Renal Failure
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US Patent:

20040068006, Apr 8, 2004
Filed:

Oct 3, 2003
Appl. No.:

10/679040
Inventors:

Mitchell Fink - Pittsburgh PA, US
Howland Warren - Cambridge MA, US
Assignee:

Critical Therapeutics, Inc. - Cambridge MA
International Classification:

A61K031/22
A61K031/16
US Classification:

514/546000, 514/625000
Abstract:

Disclosed is a method of treating acute renal failure in a subject. The method comprises the step of administering to the subject an effective amount of a composition comprising a 2-ketoalkanoic acid, a pharmaceutically acceptable salt of a 2-ketoalkanoic acid, an ester of a 2-ketoalkanoic acid, or an amide of a 2-ketoalkanoic acid. Preferably, the composition comprises an enolization agent and an alkyl aralkyl, alkoxyalkyl or carboxyalkyl ester of a 2-ketoalkanoic acid dissolved in a pharmaceutically acceptable vehicle.

Use Of Hmgb Fragments As Anti-Inflammatory Agents
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US Patent:

20080167234, Jul 10, 2008
Filed:

Sep 19, 2007
Appl. No.:

11/901963
Inventors:

Kevin J. Tracey - Old Greenwich CT, US
Huan Yang - Douglaston NY, US
Howland Shaw Warren - Cambridge MA, US
Mitchell P. Fink - Pittsburgh PA, US
International Classification:

A61K 38/17
C07K 14/435
C12N 15/63
C07K 16/18
A61P 37/00
US Classification:

514 12, 530324, 4353201, 5303879, 5303882, 5303873
Abstract:

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Use Of Hmgb Fragments As Anti-Inflammatory Agents
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US Patent:

20080214454, Sep 4, 2008
Filed:

Sep 19, 2007
Appl. No.:

11/901880
Inventors:

Kevin J. Tracey - Old Greenwich CT, US
Huan Yang - Douglaston NY, US
Howland Shaw Warren - Cambridge MA, US
Mitchell P. Fink - Pittsburgh PA, US
International Classification:

A61K 38/16
A61P 29/00
US Classification:

514 12
Abstract:

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Treatment Of Inflammation By Non-Invasive Stimulation
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US Patent:

20080249439, Oct 9, 2008
Filed:

Mar 13, 2008
Appl. No.:

12/048114
Inventors:

Kevin J. Tracey - Old Greenwich CT, US
Howland Shaw Warren - Cambridge MA, US
Michael Allen Faltys - Valencia CA, US
Assignee:

The Feinstein Institute for Medical Research - Manhasset NY
International Classification:

A61H 1/00
US Classification:

601 46
Abstract:

Described herein are devices, systems and method for treating inflammatory disorders by modulating a subject's inflammatory reflex. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject in a manner which significantly reduces proinflammatory cytokines in the subject and/or provides a therapeutically effective treatment for the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.

Devices And Methods For Inhibiting Granulocyte Activation By Neural Stimulation
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US Patent:

20090062874, Mar 5, 2009
Filed:

Aug 26, 2008
Appl. No.:

12/198808
Inventors:

Kevin J. Tracey - Old Greenwich CT, US
Howland Shaw Warren - Cambridge MA, US
Christine N. Metz - Great Neck NY, US
International Classification:

A61N 1/00
US Classification:

607 2
Abstract:

Described herein are methods, devices and systems for inhibition of granulocyte activation by appropriate stimulation of the vagus nerve. Methods of treating granulocyte-mediated disorders (including inflammatory disorders) by stimulating the vagus nerve to inhibit granulocyte activation (particularly neutrophil activation) are also described. Appropriate stimulation may be very low levels of stimulation, including stimulation that does not result in desensitization. The level of granulocyte activation may be detected and used to at least partially control stimulation.

Treatment Of Bleeding By Non-Invasive Stimulation
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US Patent:

20210251848, Aug 19, 2021
Filed:

Feb 8, 2021
Appl. No.:

17/170772
Inventors:

- Manhasset NY, US
Howland Shaw WARREN - Cambridge MA, US
Michael Allen FALTYS - Valencia CA, US
Carol Ann AMELLA - East Northport NY, US
Christopher CZURA - Lake Grove NY, US
Jared M. HUSTON - New York NY, US
International Classification:

A61H 39/04
A61H 23/00
Abstract:

Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.