Dr. Lin graduated from the Coll of Med Natl Taiwan Univ, Taipei, Taiwan (244 02 Eff 1/1971) in 1967. He works in Covina, CA and specializes in Pediatrics.
Jingtai Cao - Chappaqua NY, US Li-Hsien Wang - Somers NY, US Hsin Chieh Lin - Yorktown Heights NY, US Mark W. Sleeman - Mahopac NY, US Stanley J. Wiegand - Croton-on-Hudson NY, US
Assignee:
Regeneron Pharmaceuticals, Inc. - Tarrytown NY
International Classification:
A61K 38/18 C07K 14/71 C12N 15/62
US Classification:
4241341, 4241921, 514 2, 514 12, 530350, 536 234
Abstract:
Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. A preferred inhibitor of VEGF-mediated activity is a VEGF antagonist such as the VEGF fusion protein trap of SEQ ID NO:2 capable of binding and blocking VEGF. The method of the invention may be combined with other therapies, such as with insulin therapy.
Yi Wei - New York NY, US Lynn MacDonald - White Plains NY, US Hsin Chieh Lin - Yorktown Heights NY, US
Assignee:
Regeneron Pharmaceuticals Inc. - Tarrytown NY
International Classification:
C12Q 1/68 C40B 40/08 C40B 30/00
US Classification:
435 6, 506 17, 506 7
Abstract:
Methods and compositions for selecting ES cells that are germline competent are provided, including gene expression arrays of from one to about 300 or more genes. Selecting ES cells that are competent for germline transmission by comparing the expression of one or more genes between an ES cell that is competent at germline transmission with an ES cell of interest is described. Selecting ES cells likely to be competent at germline transmission, based on their level of expression of gtl2, is also described.
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The work was carried out in close collaboration with the group of Professor Hsin Lin at the Institute of Physics, Academia Sinica in Taiwan, and Professor Claudia Felser at the Max Planck Institute for the Chemical Physics of Solids in Dresden, Germany, including postdoctoral researcher Kaustuv Mann