Huan Qian Li

US Patent:

7842712, Nov 30, 2010

Filed:

Aug 20, 2007

Appl. No.:

11/841233

Inventors:

Alex Aronov - Watertown MA, US
David J. Lauffer - Stow MA, US
Huan Qiu Li - Cambridge MA, US
Ronald Charles Tomlinson - Marlborough MA, US
Pan Li - Arlington MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/416
C07D 231/56

US Classification:

514405, 5483615, 546119, 544262, 514258, 514303

Abstract:

The present invention provides compounds of formula I:These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.

US Patent:

7262200, Aug 28, 2007

Filed:

Oct 27, 2003

Appl. No.:

10/694534

Inventors:

Alex Aronov - Watertown MA, US
David J. Lauffer - Stow MA, US
Huan Qui Li - Cambridge MA, US
Ronald Charles Tomlinson - Marlborough MA, US
Pan Li - Arlington MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/517
C07D 403/14

US Classification:

514260, 544284, 544122, 544182, 544279, 544291, 544324, 5462757, 548181, 5483615, 435184, 514242, 514338, 514370, 514405

Abstract:

The present invention provides compounds of formula I:These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.