Hui Juan Tan

US Patent:

20210299107, Sep 30, 2021

Filed:

May 25, 2021

Appl. No.:

17/330386

Inventors:

- New York NY, US
Arie Zask - New York NY, US
Hui Tan - New York NY, US
Jacob Daniels - New York NY, US

International Classification:

A61K 31/4245
C07D 271/10
C07D 263/32
C07C 229/60
C07C 233/65
C07D 295/13
C07D 213/74
C07D 413/04
C07D 213/80
C07D 413/12
A61P 39/06
A61P 31/06
A61K 31/421
A61K 31/245
A61K 31/166
A61K 31/5375
A61K 31/44
A61K 31/4439

Abstract:

The present disclosure provides, inter alia, a compound having the structure:Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, methods for treating or ameliorating the effects of a neurodegenerative disease, methods for alleviating side effects in a subject undergoing radiotherapy and/or immunotherapy, and methods for treating or ameliorating the effects of an infection associated with ferroptosis in a subject.