Hui H Yu

US Patent:

8552205, Oct 8, 2013

Filed:

Nov 20, 2008

Appl. No.:

12/745439

Inventors:

Antonio Jose del Moral Barbosa, Jr. - Middlebury NY, US
Joerg Martin Bentzien - White Plains NY, US
Steven Richard Brunette - New Milford CT, US
Zhidong Chen - New Milford CT, US
Derek Cogan - Sandy Hook CT, US
Donghong A. Gao - Hopewell Junction NY, US
Joshua Courtney Horan - Danbury CT, US
Jennifer A. Kowalski - New Milford CT, US
Michael David Lawlor - Seymour CT, US
Rene Marc Lemieux - Newtown CT, US
Weimin Liu - Sandy Hook CT, US
Bryan McKibben - New Milford CT, US
Craig Andrew Miller - Norwalk CT, US
Neil Moss - Ridgefield CT, US
Matt Aaron Tschantz - Newtown CT, US
Zhaoming Xiong - Brookfield CT, US
Hui Yu - New Milford CT, US
Yang Yu - Danbury CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

A61K 31/4188
C07D 403/14
C07D 403/12
C07D 401/12
C07D 401/14

US Classification:

5483031, 544138, 544139, 544238, 544279, 544333, 546122, 546194, 546199, 5462731, 548113, 548136, 548181, 548132, 548235, 548250, 5482664

Abstract:

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

US Patent:

20210130868, May 6, 2021

Filed:

Apr 5, 2018

Appl. No.:

16/500370

Inventors:

- Scottsdale AZ, US
Shaopeng Wang - Chandler AZ, US
Hui Yu - Tempe AZ, US

Assignee:

Arizona Board of Regents on behalf of Arizona State University - Scottsdale AZ

International Classification:

C12Q 1/18
G01N 21/51
G06T 7/00
G16H 10/40
G16H 30/40
G16H 50/20

Abstract:

A method for deep learning video microscopy-based antimicrobial susceptibility testing of a bacterial strain in a sample by acquiring image sequences of individual bacterial cells of the bacterial strain in a subject sample before, during, and after exposure to each antibiotic at different concentrations. The image sequences are compressed into static images while preserving essential phenotypic features. Data representing the static images is input into a pre-trained deep learning (DL) model which generates output data; and antimicrobial susceptibility for the bacterial strain is determined from the output data.

US Patent:

20200009125, Jan 9, 2020

Filed:

Jun 17, 2019

Appl. No.:

16/443324

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/196
A61K 31/192
A61K 9/14

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20170252332, Sep 7, 2017

Filed:

May 10, 2017

Appl. No.:

15/591829

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/192
A61K 9/14
A61K 31/196

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20160299069, Oct 13, 2016

Filed:

Jan 2, 2015

Appl. No.:

15/038629

Inventors:

- Scottsdale AZ, US
Hui Yu - Scottsdale AZ, US
Xiaonan Shan - Scottsdale AZ, US
Shaopeng Wang - Scottsdale AZ, US

International Classification:

G01N 21/552

Abstract:

Method and system to remove background noise with a differential approach in optical imaging is disclosed. The differential approach moves the sample position laterally over a small distance, and a differential image is generated from the images recorded before and after the lateral translation. This approach can significantly improve the image quality of objects, including single DNA molecules, for label-free optical imaging techniques, such as surface plasmon resonance imaging. Disclosed imaging technique provides high-resolution genome-wide restriction maps of single DNA molecules.

US Patent:

20150182457, Jul 2, 2015

Filed:

Dec 30, 2014

Appl. No.:

14/585700

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 9/10
A61K 47/38
A61K 31/4545
A61K 47/26
A61K 31/196
A61K 31/192
A61K 31/4365
A61K 47/32

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.