Hui Zhang

US Patent:

6377972, Apr 23, 2002

Filed:

Jan 19, 1999

Appl. No.:

09/233407

Inventors:

Katherine Hua Guo - Eatontown NJ
Markus Andreas Hofmann - Tinton Falls NJ
Tze Sing Eugene Ng - Pittsburgh PA
Sanjoy Paul - Marlboro NJ
Hui Zhang - Pittsburgh PA

Assignee:

Lucent Technologies Inc. - Murray Hill NJ

International Classification:

G06F 1516

US Classification:

709201, 709231, 709238

Abstract:

A new architecture and operational techniques for supporting high quality live and on-demand streaming multimedia on a data network. By using Helper machines inside the network as data forwarding, caching, and buffering agents, and by forming meshes among Helper machines, advantages of homogeneous, synchronous multicast transmission and of heterogeneous, asynchronous reception are achieved. The architecture provides essentially transparently support to the receivers for near-zero start-up latency, improved playback quality, improved CR-like operations. These are achieved while reducing network and server load compared to todays multimedia networking techniques.

US Patent:

7198896, Apr 3, 2007

Filed:

Jun 19, 2002

Appl. No.:

10/175486

Inventors:

John Rush - Brookline MA, US
Hui Zhang - Seattle WA, US
Xiangming Zha - Beverly MA, US
Michael J. Comb - Manchester MA, US
Yi Tan - Lynnfield MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C12Q 1/00
C12Q 1/37
C12P 21/06
G01N 33/543

US Classification:

435 6, 435 4, 435 691, 435 24, 435174, 436518, 436 89, 436501, 216601, 216661, 216656

Abstract:

The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS—MS), and/or MSanalysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

US Patent:

7259022, Aug 21, 2007

Filed:

Nov 13, 2001

Appl. No.:

10/014485

Inventors:

Michael J. Comb - Manchester MA, US
Yi Tan - Lynnfield MA, US
Hui Zhang - Seattle WA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

A61K 38/00
C07K 16/00

US Classification:

436547, 436548, 5303871, 5303881

Abstract:

A method is provided for producing motif-specific, context-independent antibodies which recognize a plurality of peptides or proteins within a genome that contain the same motif. The method includes the step of immunizing a host with a degenerate peptide library antigen featuring (i) a fixed target motif containing one or more invariant amino acids including at least one modified amino acid, and (ii) a plurality of degenerate amino adds flanking the motif. Motif-specific, context-independent antibodies produced by the disclosed method are also provided. The method encompasses motifs consisting of a single modified amino acid, as well as short motifs comprising multiple invariant amino acids including one or more modified amino acids, such as all or part of kinase consensus substrate motifs, protein-protein binding motifs, or other cell signaling motifs. Methods of using the antibodies, e. g. for genome-wide profiling, are also provided.

US Patent:

7300753, Nov 27, 2007

Filed:

Feb 12, 2004

Appl. No.:

10/777893

Inventors:

John Rush - Brookline MA, US
Hui Zhang - Seattle WA, US
Xiangming Zha - Iowa City IA, US
Michael J. Comb - Manchester MA, US
Yi Tan - Lynnfield MA, US

International Classification:

C12Q 1/00
C12Q 1/37
C12P 21/06
G01N 33/543

US Classification:

435 6, 435 4, 435 691, 435 24, 435174, 436518, 436 89, 436501, 216601, 216661, 216656

Abstract:

The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS—MS), and/or MSanalysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

US Patent:

7398312, Jul 8, 2008

Filed:

Mar 29, 2000

Appl. No.:

09/538351

Inventors:

Katherine H. Guo - Eatontown NJ, US
Markus A. Hofmann - Tinton Falls NJ, US
Sanjoy Paul - Marlboro NJ, US
Tze Sing Eugene Ng - Pittsburgh PA, US
Hui Zhang - Pittsburgh PA, US

Assignee:

Lucent Technologies Inc. - Murray Hill NJ

International Classification:

G06F 15/173
G06F 15/16
G06F 12/00
G06F 13/00
G06F 13/28

US Classification:

709226, 709225, 709231, 711118

Abstract:

An apparatus and method to enhance existing caches in a network to better support streaming media storage and distribution. Helper machines are used inside the network to implement several methods which support streaming media including segmentation of streaming media objects into smaller units, cooperation of Helper machines, and novel placement and replacement policies for segments of media objects.

US Patent:

7426575, Sep 16, 2008

Filed:

May 14, 2001

Appl. No.:

09/859192

Inventors:

Bob Reissfelder - Westwood MA, US
Yantao Jia - Stow MA, US
Lei Jin - Irvine CA, US
Shahzad Ali - Rohnert Park CA, US
Stephen John West - Petaluma CA, US
Hui Zhang - Santa Rosa CA, US
Shuangxia Sarah Zhu - Rohnert Park CA, US

Assignee:

Turin Networks - Petaluma CA

International Classification:

G06F 15/173
G06F 15/16

US Classification:

709240, 709231, 709238

Abstract:

An arriving cell is admitted when a flow occupancy level is less than a flow minimum threshold. When the flow occupancy level is not less than the flow minimum threshold, a drop probability based on per-class thresholds is applied to determine if the arriving is to be rejected. When the arriving cell is not to be rejected after applying the drop probability based on the per-class thresholds, a drop probability based on per-flow thresholds is applied.

US Patent:

7526564, Apr 28, 2009

Filed:

Mar 4, 2002

Appl. No.:

10/090110

Inventors:

Katherine Hua Guo - Eatontown NJ, US
Markus Andreas Hofmann - Tinton Falls NJ, US
Tze Sing Eugene Ng - Pittsburgh PA, US
Sanjoy Paul - Marlboro NJ, US
Hui Zhang - Pittsburgh PA, US

Assignee:

Alcatel-Lucent USA Inc. - Murray Hill NJ

International Classification:

G06F 15/16

US Classification:

709231, 709235

Abstract:

A new architecture and operational techniques for supporting high quality live and on-demand streaming multimedia on a data network. By using Helper machines inside the network as data forwarding, caching, and buffering agents, and by forming meshes among Helper machines, advantages of homogeneous, synchronous multicast transmission and of heterogeneous, asynchronous reception are achieved. The architecture provides essentially transparently support to the receivers for near-zero start-up latency, improved playback quality, improved CR-like operations. These are achieved while reducing network and server load compared to today's multimedia networking techniques.

US Patent:

7639611, Dec 29, 2009

Filed:

Mar 10, 2006

Appl. No.:

11/372898

Inventors:

Fang Hao - Morganville NJ, US
Muralidharan Sampath Kodialam - Marlboro NJ, US
Hui Zhang - New Brunswick NJ, US

Assignee:

Alcatel-Lucent USA Inc. - Murray Hill NJ

International Classification:

G01R 31/08

US Classification:

370230

Abstract:

The invention includes a method and apparatus for generating a coincidence count table adapted for determining at least one flow statistic. The method includes receiving a plurality of packets comprising a respective plurality of payloads, comparing payloads associated with consecutive ones of the plurality of packets for identifying at least one simple pattern included within the compared payloads of the consecutive ones of the plurality of packets, for each of the consecutive ones of the plurality of packets, if the at least one simple pattern is identified, processing the at least one simple pattern to form a complex pattern, and for each complex pattern, updating a coincidence count associated with the complex pattern, wherein the coincidence counts are adapted for determining at least one flow statistic.