Hui Zhang - Philadelphia PA Roger J. Pomerantz - Chalfont PA Bin Yang - Bala Cynwyd PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 3804
US Classification:
530327, 530324, 530325, 530326, 530826
Abstract:
One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif, by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.
Multimerization Of Hiv-1 Vif Protein As A Therapeutic Target
Hui Zhang - Philadelphia PA, US Roger J. Pomerantz - Chalfont PA, US Bin Yang - Bala Cynwyd PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C12Q 1/68
US Classification:
435 6, 435 911, 435 9133
Abstract:
One approach to treating individuals infected with HIV-1 is to administer to such individuals compounds that directly interfere with and intervene in the machinery by which HIV-1 replicates itself within human cells. Although the specific role of HIV-1 viral protein Vif in the viral life cycle is not known, the vif gene is essential for the pathogenic replication of lentiviruses in vivo. The present invention relates to a method for treating an individual exposed to or infected with HIV-1. Individuals identified as being exposed to or infected by HIV-1 are administered a therapeutically effective amount of one or more compounds that inhibit or prevent replication of said HIV-1 by interfering with the replicative or other essential functions of HIV-1 viral protein Vif by interactively blocking the multimerization domain of Vif, thereby preventing multimerization of Vif protein, which is important for Vif function in the lentivirus life cycle. In preferred embodiments, the compound or compounds that interactively block the multimerization domain of Vif are Vif antagonists. Pharmaceutical compositions comprising these compounds are also disclosed.
Multimerization Of Hiv-1 Vif Protein As A Therapeutic Target
Hui Zhang - Philadelphia PA, US Roger J. Pomerantz - Chalfont PA, US Bin Yang - Bala Cynwyd PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C12Q 1/68
US Classification:
435 6, 435 911
Abstract:
The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.
A compound of the formula X-M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X-M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.
Method For Increasing Transduction Efficiency Of Recombinant Retroviral Vectors
Hui Zhang - Philadelphia PA Roger J. Pomerantz - Chalfont PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C12N 1500 C12N 1586 C12N 510
US Classification:
4351723
Abstract:
A method for improving the transduction efficiency of retroviral vectors into a host cell wherein the retroviral vectors are incubated with deoxyribonucleoside triphosphates prior to transduction into the host cell is provided.
Compounds Having Estrogen Receptor Alpha Degradation Activity And Uses Thereof
- Brooklyn NY, US Ke Liu - Shanghai, CN Hui Zhang - Brooklyn NY, US Wei He - Zionsville IN, US
Assignee:
Accutar Biotechnology Inc. - Brooklyn NY
International Classification:
C07D 401/14 C07D 471/10 C07D 401/04 A61P 35/00
Abstract:
The present disclosure relates to novel compounds having estrogen receptor alpha degradation activity, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.
Novel Compounds Having Estrogen Receptor Alpha Degradation Activity And Uses Thereof
- Brooklyn NY, US Ke Liu - Shanghai, CN Hui Zhang - Brooklyn NY, US Wei He - Zionsville IN, US
Assignee:
ACCUTAR BIOTECHNOLOGY INC. - Brooklyn NY
International Classification:
C07D 401/14 A61P 35/00 C07D 401/04 C07D 471/10
Abstract:
The present disclosure relates to novel compounds having estrogen receptor alpha degradation activity, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.
Log-Based Computer System Failure Signature Generation
- Princeton NJ, US Jianwu Xu - Lawrenceville NJ, US Hui Zhang - Princeton Junction NJ, US
International Classification:
G06F 11/07
Abstract:
Systems and methods for automatically generating failure signatures in a computer system for performing computer system fault diagnosis are provided. The method includes receiving log data, converting each log in the log data into a collection of log pattern sequences including one or more log pattern sequences corresponding to one or more respective failure categories associated with the computer system, generating a collection of seed patterns by computing a global set of patterns from the collection of log pattern sequences, and extracting the collection of seed patterns from the global set of patterns, generating a log pattern grammar representation for each of the one or more log pattern sequences, generating a failure signature for each of the one or more failure categories based on the log pattern grammar representation and the collection of seed patterns, and employing the failure signatures to perform computer system fault diagnosis on new log data.
Name / Title
Company / Classification
Phones & Addresses
Hui Ling Zhang Director, President
Freddy Cafe of Auburndale Inc
569 Berkley Rd, Auburndale, FL 33823 PO Box 130404, New York, NY 10013
Hui Zhang Principal
Huizhang Inc Business Services at Non-Commercial Site
89 W 45 St, Bergen Point, NJ 07002
Hui M. Zhang Principal
Gdj Consulting Inc Business Consulting Services
109 Lafayette St, New York, NY 10013
Hui Dong Zhang Manager
X Y C NEW ENGLAND LLC Nonclassifiable Establishments
194 Chandler St, Worcester, MA 01609 196 Chandler St, Worcester, MA 01609
Hui Juan Zhang
BOBO DELIVERY INC
50-11 Jct Blvd, Elmhurst, NY 11373 5011 Jct Blvd, Elmhurst, NY 11373
Hui Zhang
RETRO VAPE LLC
Hui Zhang
NANO GLOBAL SOFTWARE SOLUTIONS LLC
Hui Zhang
FEIYI AMERICAN, INC
61-52 224, Oakland Gardens, NY 11364 61-52 224 St, Bayside, NY
Dec 2012 to Jul 2013 Marketing&PR Assistantmeici.com
Oct 2011 to Apr 2012 SalesJoyce Boutique (China) Limited
Jan 2011 to Feb 2012 Assistant
Education:
New York Institute of Technology New York, NY 2013 to 2015 Master of Art in Communication ArtsFudan University 2008 to 2012 Bachelor of Art in Fashion Design
Skills:
Language Abilities: Bilingual in English and Chinese ; Computer Skills: Microsoft Word, Power Point, Excel & Applework; Design Software: Photoshop, After Effects, Dreamweaver, maya
Stevens Institute of Technology Hoboken, NJ Mar 2014 to May 2014 DesignerThe Louis Berger Group Morristown, NJ Sep 2012 to May 2013 Senior Design ProjectStevens Institute of Technology Hoboken, NJ Jan 2012 to May 2012 Designer
Education:
Stevens Institute of Technology Hoboken, NJ Dec 2014 Master of Engineering in Structural Engineering
Skills:
CAD Software: Revit Architecture & Structure, AutoCAD, MicroStation, HEC-HMS, HydroCAD, MS Office: Word, PowerPoint, and Excel Other: MathCAD, Photoshop, SolidWorks
May 2013 to 2000 Senior quantitative researcherPortfolio Analytics/ALPHA, Bloomberg L.P New York, NY Apr 2007 to May 2013 Senior ResearcherFirmwide risk modeling, Goldman, Sachs & Co New York, NY Sep 2004 to Apr 2007 Risk model researcherFriedrich, Klatt and Associates Chicago, IL May 2000 to Dec 2002 Statistical arbitrage trading strategy development in equity derivatives
Education:
University of Chicago Chicago, IL Jun 2003 M.S. in Financial Mathematicsthe University of Chicago Chicago, IL May 2002 Ph.D. in Fluid DynamicsInstitute of Biophysics Jun 1993 M.S. in Neural NetworkPeking University Jun 1990 B.S. in Physics
2012 to 2000 Risk Manager, Trading StrategistKoch Supply & Trading Houston, TX 2007 to 2011 Senior StrategistDynamis Energy Trading New York, NY 2006 to 2007 Director of Risk Management and Trading AnalyticsStark Investments New York, NY 2004 to 2006 TraderKeySpan Energy New York, NY 2002 to 2004 Risk ManagerWilliams Energy Marketing and Trading Tulsa, OK 2000 to 2002 Senior Trading AnalystRegional Economic Research, Inc San Diego, CA 1999 to 1999 Consultant
Education:
Claremont Graduate University Claremont, CA May 2001 Ph.D. in Economics and Political SciencePeking University 1997 Master of Arts in Economics
Oct 2011 to Present Investment Research AnalystShangpin Foods Co., Ltd Jiangsu, China Jun 2009 to Aug 2009 Database Marketing Analyst InternChina Construction Bank Jiangsu, China Jun 2008 to Aug 2008 Credit and Loan Department Intern
Education:
Columbia University, Graduate School of Arts and Sciences New York, NY Jan 2010 to Jan 2012 MA in StatisticsNanjing University Nanjing, China Jan 2006 to Jan 2010 BS in Mathematics
Skills:
SAS(Certified Programmer), R, MATLAB, C++, VBA, Pascal, Microsoft Word, Excel, PowerPoint
Alternative Asset Investment Management Securities, LLC New York, NY Oct 2012 to Dec 2012 Capital Raising InternAlternative Asset Investment Management Securities, LLC New York, NY Sep 2012 to Oct 2012 Alternative Asset Summit CoordinatorChina, Ltd Changchun, CN Jun 2011 to Aug 2011 Underwriting Intern
Education:
Jilin University Changchun, CN Aug 2011 to May 2012 FinanceUniversity of Nebraska-Lincoln Lincoln, NE May 2012 Master of Science in Actuarial Science
Medicine Doctors
Hui Zhang, Elmhurst NY - PA (Physician assistant; also Posterior–anterior)
Yale University School Genetics Consultation Services 3333 Cedar St, New Haven, CT 06510 2037852660 (phone), 2037853404 (fax)
Education:
Medical School Shanghai Med Univ, Shanghai First Med Univ, Shanghai, China Graduated: 1988
Conditions:
Cleft Palate and Cleft Lip Hearing Loss Undescended and Retractile Testicle
Languages:
English Spanish
Description:
Dr. Zhang graduated from the Shanghai Med Univ, Shanghai First Med Univ, Shanghai, China in 1988. She works in New Haven, CT and specializes in Genetics, Medical. Dr. Zhang is affiliated with Yale New Haven Hospital.
HSHS Medical GroupHSHS Medical Group Cancer Institute 301 N 8 St, Springfield, IL 62701 2175255640 (phone), 2177576754 (fax)
HSHS Medical GroupHSHS Medical Group Cancer Institute 1215 Franciscan Dr FL 2, Litchfield, IL 62056 2175255640 (phone), 2173248740 (fax)
Languages:
English
Description:
Dr. Zhang works in Litchfield, IL and 1 other location and specializes in Hematology/Oncology and Internal Medicine. Dr. Zhang is affiliated with Saint Francis Hospital, Saint Johns Hospital and Saint Marys Hospital.
The study is titled Formation of memory assemblies through the DNA sensing TLR9 pathway. Other Einstein authors are: Hui Zhang, Ph.D., Zorica Petrovic, B.A., Anna Carboncino, Ph.D., Kendra K. Parker, B.A., Thomas E. Bassett, Ph.D., Xusheng Zhang, M.S.
Date: Mar 27, 2024
Category: Health
Source: Google
Study Warns: Vitamin D Deficiency May Raise Risk of Getting COVID-19
Reference: Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results by David O. Meltzer, MD, PhD; Thomas J. Best, PhD; Hui Zhang, PhD; Tamara Vokes, MD; Vineet Arora, MD, MPP and Julian Solway, MD, 3 September 2020, JAMA Network Open.DOI: 10.1001/jamanetworkop
"While a plutonium bomb requires the assembly of a complicated weapons system to deal with pre-detonation issues, a HEU bomb is relatively easy to construct," Harvard physicist Hui Zhang wrote in an analysis for the Bulletin of the Atomic Scientists. "Moreover, unlike plutonium, HEU poses no signifi
Eight people appeared in Simcoe court Wednesday: Jing Ming Chen, 38, of Markham, Bin Ni, 41 of Ajax, Kien Sheng Kwok, 55, Zhong Yang, 43, Xiao Hui Zhang, 41, Yu Chen, 34, Hao Ran Liu, 24, and Xiang Lin, 37, all of Toronto, are charged with production ...
Microscopy, quantum-style: Atomic stacks imaged in real space
The research team Yong-hui Zhang, working with Peter Wahl and Professor Klaus Kern based their QPCM technique on low-temperature STM, and in fact QPCM operates in a low-temperature scanning tunneling microscope at 6 K (-267 C) in an ultra-high ...
In a recent interview with Chinese media Volvo's China CEO, Zhang Shen Hui, revealed that the company's plans for two new factories in Chengdu and Daqing are currently with the government and awaiting approval, it is expected that the company will gain ...
Min Xin Holdings Ltd : Notice of Extraordinary General Meeting
As at the date of this announcement, the Executive Directors of the Company are Messrs Weng Ruo Tong (Chairman), Wang Hui Jin (Vice Chairman), Zhu Xue Lun and Li Jin Hua; the Non-Executive Director is Mr Zhang Rong Hui; and the Independent ...