Huilan Gao

US Patent:

20200157212, May 21, 2020

Filed:

Jun 8, 2018

Appl. No.:

16/614701

Inventors:

- New York NY, US
- Boston MA, US
Eric M. Bennett - Arlington MA, US
Huilan Gao - West Roxbury MA, US
Zong Sean Juo - Cambridge MA, US
Stefano V. Gulla - Boston MA, US
Christine Huard - Somerville MA, US
Sreekumar R. Kodangattil - Lexington MA, US
Jian Li - Chestnut Hill MA, US
Weining Lu - Boston MA, US
Xueping Fan - Boston MA, US
David J. Salant - Boston MA, US

International Classification:

C07K 16/28
A61P 13/12
C12N 15/85

Abstract:

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

US Patent:

20200095334, Mar 26, 2020

Filed:

Jul 22, 2016

Appl. No.:

15/746305

Inventors:

- Oakland CA, US
- New York NY, US
Huilan GAO - West Roxbury MA, US
Yun KIM - Walnut Creek CA, US
Isaac J. RONDON - San Francisco CA, US
Tovo DAVID - San Francisco CA, US
Shaun R. COUGHLIN - Tiburon CA, US

International Classification:

C07K 16/36

Abstract:

In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.