Ian Cook

US Patent:

8380315, Feb 19, 2013

Filed:

Oct 5, 2010

Appl. No.:

12/898686

Inventors:

Christopher DeGiorgio - Valencia CA, US
Ian A. Cook - Los Angeles CA, US
Alejandro Covalin - Culver City CA, US
Patrick R. Miller - Santa Monica CA, US
Lara Schrader - Pacific Palisades CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 1/00

US Classification:

607 45

Abstract:

The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

US Patent:

20110106220, May 5, 2011

Filed:

Oct 5, 2010

Appl. No.:

12/898696

Inventors:

Christopher DeGiorgio - Valencia CA, US
Ian A. Cook - Los Angeles CA, US
Leon Ekchian - Glendale CA, US

Assignee:

The Regents of the University of California - Oakland CA
Neurosigma, Inc. - Los Angeles CA

International Classification:

A61N 1/36

US Classification:

607 72

Abstract:

The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.

US Patent:

20110112603, May 12, 2011

Filed:

Oct 5, 2010

Appl. No.:

12/898685

Inventors:

Christopher DEGIORGIO - Valencia CA, US
Ian A. COOK - Los Angeles CA, US
Leon EKCHIAN - Glendale CA, US

Assignee:

The Regents of the University of California - Oakland CA
Neurosigma, Inc. - Los Angeles CA

International Classification:

A61N 1/36
A61N 1/05

US Classification:

607 45, 607116

Abstract:

The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

US Patent:

20110218589, Sep 8, 2011

Filed:

Oct 5, 2010

Appl. No.:

12/898675

Inventors:

Christopher DeGIORGIO - Valencia CA, US
Ian A. COOK - Los Angeles CA, US
Alejandro COVALIN - Culver City CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61N 1/36
A61N 1/04

US Classification:

607 45, 607115

Abstract:

The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

US Patent:

20130158626, Jun 20, 2013

Filed:

Feb 15, 2013

Appl. No.:

13/769074

Inventors:

The Regents of the University of California - Oakland CA, US
Ian A. Cook - Los Angeles CA, US
Alejandro Covalin - Culver City CA, US
Patrick R. Miller - Santa Monica CA, US
Lara Schrader - Pacific Palisades CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61N 1/36
A61N 1/05

US Classification:

607 45, 607116

Abstract:

The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

US Patent:

20140081353, Mar 20, 2014

Filed:

Nov 30, 2011

Appl. No.:

13/990348

Inventors:

Ian A. Cook - Los Angeles CA, US
Christopher M. DeGiorgio - Valencia CA, US
Leon Ekchian - Glendale CA, US
Patrick Miller - Santa Monica CA, US
Colin Kealey - Los Angeles CA, US

Assignee:

NEUROSIGMA, INC. - Los Angeles CA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61N 1/36

US Classification:

607 59

Abstract:

Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.

US Patent:

52693155, Dec 14, 1993

Filed:

Aug 16, 1991

Appl. No.:

7/745872

Inventors:

Andrew F. Leuchter - Los Angeles CA
Ian A. Cook - Beverly Hills CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 50476

US Classification:

128731

Abstract:

Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases.

US Patent:

53099230, May 10, 1994

Filed:

Aug 12, 1992

Appl. No.:

7/929192

Inventors:

Andrew F. Leuchter - Los Angeles CA
Ian A. Cook - Beverly Hills CA

Assignee:

The Regents of the University of California - Alameda CA

International Classification:

A61B 50476

US Classification:

128731

Abstract:

Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases. Mapping is used to determine activation during tasks such as motor and memory tasks, cognitive processing or other conditions, and also to assess the level of perfusion of the brain.