Ian R Nelson

US Patent:

6867591, Mar 15, 2005

Filed:

Dec 19, 2003

Appl. No.:

10/741610

Inventors:

Ian Nelson - Chapel Hill NC, US

Assignee:

Medi-Physics, Inc. - Princeton NJ

International Classification:

G01V003/00

US Classification:

324317, 324308

Abstract:

A device for simulating a sample of gas having a specific level of polarization when measured by a NMR pickup coil includes an active circuit loosely coupled to the NMR pickup coil. The active circuit responds as a hyperpolarized gas having the specific level of polarization when measured by the NMR pickup coil.

US Patent:

7127934, Oct 31, 2006

Filed:

May 15, 2003

Appl. No.:

10/438464

Inventors:

Zivko Djukic - Durham NC, US
Steve Kadlecek - Carrboro NC, US
John Nouls - Raleigh NC, US
Ian Nelson - Chapel Hill NC, US
Bastiaan Driehuys - Chapel Hill NC, US

Assignee:

Medi-Physics, Inc. - Princeton NJ

International Classification:

G01N 27/00

US Classification:

73 232, 73 2401, 73 2406

Abstract:

A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an NMR coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to the optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit. A polarimetry circuit for determining polarization of a gas includes an NMR coil that may be configured to excite a polarized gas and be responsive to an electromagnetic signal generated by the excited, polarized gas.

US Patent:

7275413, Oct 2, 2007

Filed:

Nov 16, 2005

Appl. No.:

11/280069

Inventors:

Zivko Djukic - Durham NC, US
Steve Kadlecek - Carrboro NC, US
John Nouls - Raleigh NC, US
Ian Nelson - Chapel Hill NC, US
Bastiaan Driehuys - Chapel Hill NC, US

Assignee:

Medi-Physics, Inc. - Princeton NJ

International Classification:

G01N 24/08

US Classification:

73 232, 73 2406, 324313, 702 30

Abstract:

A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an Nuclear Magnetic Resonance (NMR) coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse that may be transmitted to an optical cell through the NMR coil to excite the polarized gas responsive to a control processor. A Q-reduction circuit that is independent of the pulse generator circuit is configured to reduce oscillations in the oscillator circuit from the transmitted electrical pulse responsive to the control processor. A receive circuit is responsive to an electrical signal that is induced in the oscillator circuit due to the electromagnetic excitation of the polarized gas. The control processor is configured to determine the polarization of the gas based on the output signal of the receive circuit. A polarimetry circuit for determining polarization of a gas includes an NMR coil that may be configured to excite a polarized gas and be responsive to an electromagnetic signal generated by the excited, polarized gas.

US Patent:

7746075, Jun 29, 2010

Filed:

Sep 18, 2007

Appl. No.:

11/856805

Inventors:

Zivko Djukic - Durham NC, US
Steve Kadlecek - Carrboro NC, US
John Nouls - Raleigh NC, US
Ian Nelson - Chapel Hill NC, US
Bastiaan Driehuys - Chapel Hill NC, US

Assignee:

Medi-Physics, Inc. - Princeton NJ

International Classification:

G01V 3/00

US Classification:

324319, 324318

Abstract:

A circuit for determining a polarization of a gas. The circuit includes a polarimetry circuit having an NMR coil that is configured to excite a polarized gas and that is responsive to an electromagnetic signal generated by the excited, polarized gas. The polarimetry circuit has a reproducible polarization measurement variability of less than about 2% when the NMR coil is exposed to a temperature in a range of about 0 C. to about 200 C.

US Patent:

20040265179, Dec 30, 2004

Filed:

Jan 20, 2004

Appl. No.:

10/760876

Inventors:

Ian Nelson - Chapel Hill NC, US
Stephen Kadlecek - Carrboro NC, US
John Nouls - Durham NC, US

International Classification:

B32B005/02
B32B027/12
F01N003/10
B32B027/04
G01N007/00
G01N031/00
G01N021/00
G01N027/00
F04B017/00
F04B047/08
G01N024/00
G01N033/00
F04B035/00

US Classification:

422/083000, 422/173000, 417/375000, 436/173000

Abstract:

A pumping system for hyperpolarized gases employs a reversible fluid flow against a deflectable gas transport bladder. Inflation and deflation of the gas transport bladder is operably associated with valves for directing the flow of the hyperpolarized gas. A second gas transport bladder may be operably associated with additional valving so as to provide more continuous hyperpolarized gas flow. The first and second gas transport bladders may be arranged in-line with a reversible pumping mechanism.