Iran B Reyes

US Patent:

20050058707, Mar 17, 2005

Filed:

Aug 3, 2004

Appl. No.:

10/910040

Inventors:

Iran Reyes - San Jose CA, US
Noymi Yam - Sunnyvale CA, US
Padmaja Shivanand - Los Altos CA, US
Shaoling Li - Sunnyvale CA, US
Patrick Wong - Burlingame CA, US

International Classification:

A61K009/22
A61K009/24

US Classification:

424468000

Abstract:

Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.

US Patent:

20050208132, Sep 22, 2005

Filed:

Feb 4, 2005

Appl. No.:

11/051060

Inventors:

Gayatri Sathyan - San Jose CA, US
Suneel Gupta - Sunnyvale CA, US
Noymi Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US
Sonya Seroff - San Jose CA, US

International Classification:

A61K031/42
A61K009/22

US Classification:

424468000, 514379000

Abstract:

Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.

US Patent:

20050232995, Oct 20, 2005

Filed:

Feb 4, 2005

Appl. No.:

11/051165

Inventors:

Nyomi Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US
Sonya Seroff - San Jose CA, US
Suneel Gupta - Sunnyvale CA, US
Gayatri Sathyan - San Jose CA, US

International Classification:

A61K031/519
A61K009/24

US Classification:

424473000, 514259410

Abstract:

Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.

US Patent:

20070166381, Jul 19, 2007

Filed:

Jan 3, 2007

Appl. No.:

11/619468

Inventors:

Iran Reyes - San Jose CA, US
Julie Lee - Sunnyvale CA, US
Brian Barclay - Sunnyvale CA, US
Iswadi Liejanto - Redwood City CA, US
Nipun Davar - Fremont CA, US

International Classification:

A61K 9/24

US Classification:

424473000

Abstract:

Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1,600 mil; and wherein the drug layer comprises from about 20 wt % to about 90 wt % microcrystalline cellulose, and less than or equal to about 10 wt % of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.

US Patent:

20090202631, Aug 13, 2009

Filed:

Apr 22, 2009

Appl. No.:

12/428422

Inventors:

Nyomi V. Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul D. Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US
Sonya Seroff - San Jose CA, US
Suneel K. Gupta - Sunnyvale CA, US
Gayatri Sathyan - San Jose CA, US

International Classification:

A61K 31/519
A61K 9/20

US Classification:

424464, 51425941

Abstract:

Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.

US Patent:

20110195981, Aug 11, 2011

Filed:

Jan 24, 2011

Appl. No.:

13/012490

Inventors:

Gayatri Sathyan - San Jose CA, US
Suneel Gupta - Sunnyvale CA, US
Noymi V. Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul D. Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US
Sonya Seroff - San Jose CA, US

International Classification:

A61K 31/519
A61P 25/18

US Classification:

51425941

Abstract:

Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.

US Patent:

20120283275, Nov 8, 2012

Filed:

May 9, 2012

Appl. No.:

13/467761

Inventors:

Gayatri Sathyan - San Jose CA, US
Suneel Gupta - Sunnyvale CA, US
Noymi V. Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul D. Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US
Sonya Seroff - San Jose CA, US

International Classification:

A61K 31/519
A61P 25/18

US Classification:

51425941

Abstract:

Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.

US Patent:

20040092534, May 13, 2004

Filed:

Jul 28, 2003

Appl. No.:

10/629211

Inventors:

Nyomi Yam - Sunnyvale CA, US
Iran Reyes - San Jose CA, US
Nipun Davar - Fremont CA, US
Atul Ayer - Palo Alto CA, US
Julie Lee - Sunnyvale CA, US

International Classification:

A61K031/519

US Classification:

514/259410

Abstract:

Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form.