Irene Huanlian Chen

US Patent:

20050164402, Jul 28, 2005

Filed:

Jan 13, 2005

Appl. No.:

11/036707

Inventors:

Christopher Belisle - Concord CA, US
John Walker - Hayward CA, US
Sarah Ngola - Sunnyvale CA, US
Douglas Greiner - Fremont CA, US
Mark Levy - San Jose CA, US
Xiaoxia Zhao - Fremont CA, US
Irene Chen - Fremont CA, US
Mark Stolowitz - Pleasanton CA, US
Donald Paquin - San Jose CA, US

International Classification:

G01N001/00

US Classification:

436174000, 422099000

Abstract:

The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

US Patent:

20080248589, Oct 9, 2008

Filed:

May 19, 2005

Appl. No.:

11/596285

Inventors:

Christopher M. Belisle - Concord CA, US
John A. Walker - Hayward CA, US
Sarah M. Ngola - Sunnyvale CA, US
Douglas P. Greiner - Fremont CA, US
Mark J. Levy - San Jose CA, US
Xiaoxia Zhao - Fremont CA, US
Irene Y. Chen - Fremont CA, US
Mark L. Stolowitz - Pleasanton CA, US
Donald P. Paquin - San Jose CA, US

International Classification:

G01N 33/543
B01J 19/00

US Classification:

436518, 422 681

Abstract:

The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

US Patent:

20110070659, Mar 24, 2011

Filed:

May 24, 2010

Appl. No.:

12/786133

Inventors:

Christopher M. Belisle - Concord CA, US
Sarah M. Ngola - Sunnyvale CA, US
Douglas P. Greiner - Fremont CA, US
Mark J. Levy - San Jose CA, US
Xiaoxia Zhao - Fremont CA, US
Irene Y. Chen - Fremont CA, US
Mark L. Stolowitz - Pleasanton CA, US
Donald P. Paquin - San Jose CA, US

Assignee:

Qiagen Sciences, Inc. - Hilde

International Classification:

G01N 33/543
G01N 1/00
G01N 33/50
B01L 9/00
G01N 21/00
G01N 21/76
G01N 24/00
G01N 30/96

US Classification:

436501, 436174, 436 86, 422566, 436164, 436172, 436173, 422 69

Abstract:

The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed.

US Patent:

20200390775, Dec 17, 2020

Filed:

Jan 10, 2020

Appl. No.:

16/740174

Inventors:

- Foster City CA, US
Irene Chen - San Mateo CA, US
Katie Ann Keaton - Niwot CO, US
Scott E. Lazerwith - Burlingame CA, US
Vahid Zia - Palo Alto CA, US

International Classification:

A61K 31/5365
C07D 498/18
A61K 45/06
A61K 9/20
C07D 498/14
A61K 31/513
A61K 31/553
A61K 31/675
A61K 31/683

Abstract:

The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-(2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

US Patent:

20190015420, Jan 17, 2019

Filed:

Jun 14, 2018

Appl. No.:

16/008931

Inventors:

- Foster City CA, US
Irene Chen - San Mateo CA, US
Katie Ann Keaton - Burlingame CA, US
Scott E. Lazerwith - Burlingame CA, US
Vahid Zia - Palo Alto CA, US

International Classification:

A61K 31/5365
C07D 498/18
C07D 498/14
A61K 31/675
A61K 9/20
A61K 31/513
A61K 45/06
A61K 31/683
A61K 31/553
A61K 31/537

Abstract:

The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

US Patent:

20180065986, Mar 8, 2018

Filed:

Jun 15, 2017

Appl. No.:

15/624166

Inventors:

- FORSTER CITY CA, US
IRENE CHEN - SAN MATEO CA, US
VAHID ZIA - PALO ALTO CA, US

International Classification:

C07D 498/18
A61K 45/06
A61K 31/685
A61K 31/537
A61K 9/20
A61K 31/513
A61K 31/675
A61K 31/553
C07D 498/14

Abstract:

The present invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

US Patent:

20170333438, Nov 23, 2017

Filed:

May 5, 2017

Appl. No.:

15/588346

Inventors:

- Foster City CA, US
Irene Chen - San Mateo CA, US
Katie Ann Keaton - Burlingame CA, US
Scott E. Lazerwith - Burlingame CA, US
Vahid Zia - Palo Alto CA, US

International Classification:

A61K 31/5365
A61K 9/20
A61K 45/06
C07D 498/18
C07D 498/14
A61K 31/537

Abstract:

The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

US Patent:

20170197985, Jul 13, 2017

Filed:

Jun 19, 2015

Appl. No.:

15/320656

Inventors:

- Foster City CA, US
Irene Chen - San Mateo CA, US
Vahid Zia - Palo Alto CA, US

International Classification:

C07D 498/18
A61K 31/513
A61K 9/20
A61K 31/685
A61K 45/06
A61K 31/537

Abstract:

The present Invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10 ((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5] pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.