Ivo Lieberam

US Patent:

20040014210, Jan 22, 2004

Filed:

Jul 16, 2002

Appl. No.:

10/196882

Inventors:

Thomas Jessell - Bronx NY, US
Hynek Wichterle - New York NY, US
Ivo Lieberam - New York NY, US

International Classification:

C12N005/06
C12N005/08
A61K038/17
A61K031/203

US Classification:

435/368000, 435/354000, 514/012000, 514/559000

Abstract:

The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

US Patent:

20070185024, Aug 9, 2007

Filed:

Aug 25, 2006

Appl. No.:

11/510038

Inventors:

Thomas Jessell - Bronx NY, US
Hynek Wichterle - New York NY, US
Sara Wilson - New York NY, US
Ivo Lieberam - New York NY, US

International Classification:

A61K 38/17
G01N 33/567
C12N 5/08
A61K 31/203
A61K 31/07

US Classification:

514012000, 435007200, 435368000, 514559000, 514725000

Abstract:

The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of a Wnt signalling pathway, a modulator of Wnt-dependent neural differentiation, a modulator of a BMP signalling pathway, a modulator of BMP-dependent neural differentiation, a modulator of a Hh signalling pathway, and a modulator of Hh-dependent neural differentiation. Also provided are modulators identified by these methods.

US Patent:

20070224650, Sep 27, 2007

Filed:

Aug 25, 2006

Appl. No.:

11/510366

Inventors:

Thomas Jessell - Bronx NY, US
Hynek Wichterle - New York NY, US
Sara Wilson - New York NY, US
Ivo Lieberam - New York NY, US

International Classification:

G01N 33/567
C12N 5/06
C12N 5/08

US Classification:

435007210, 435325000

Abstract:

The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a modulator of a retinoid signalling pathway, and a modulator of retinoid-dependent neural differentiation. Also provided are modulators identified by these methods.