A compressible extended release tablet or tablet layer having a drug release profile that is not strongly dependent on tablet hardness may be prepared by dry blending a pharmaceutically active ingredient with hydroxypropyl methylcellulose, wherein the hydroxypropyl methylcellulose has a bimodal or multimodal number average molecular weight distribution that includes at least one mode over 20,000 Daltons and at least one mode under 10,000 Daltons. An additional advantage of the invention is that the tablet formulations may be prepared without resort to wet granulation.
Sustained Release Antihistamine And Decongestant Composition
Ronald Perry - Paw Paw MI, US Jack Irwin - Kalamazoo MI, US
International Classification:
A61K 31/137 A61K 9/24
US Classification:
424471000, 514649000
Abstract:
A controlled-release, non-sedating antihistamine and decongestant composition which provides a 24-hour decongestant dissolution profile using standard ungranulated xanthan gum as the sole controlled-release agent and a process for preparing the same is provided. The pharmaceutical composition of the present invention typically includes: a compressed extended-release core comprising a pharmaceutically effective amount of decongestant, ungranulated xanthan gum, one or more binders, a flow agent, and a lubricant. An immediate-release coating composition is disposed on the core that typically includes a non-sedating antihistamine and at least one coating agent.
Jack T. Irwin - Mattawan MI Shirish A. Shah - Kalamazoo MI
Assignee:
L. Perrigo Company - Allegan MI
International Classification:
A61K 922 A61K 936
US Classification:
424468
Abstract:
Pseudoephedrine hydrochloride extended-release tablets including a sustained release hydroxypropylmethylcellulose matrix and a microcrystalline cellulose disintegrant formed by a dry mixed, direct compression method.
Name / Title
Company / Classification
Phones & Addresses
Jack Irwin President
Pacific Honda The Dick Irwin Group Ltd. Automobile Dealers-New Cars. Automobile Parts & Supplies-Retail. Automobile Leasing. Automobile Dealers-Used Cars. Automobile Repairing & Service
816 Automall Dr, Vancouver, BC V7P 3R8 6049840331, 6049862154
Mr. Jack Irwin President
Irwin Installers Ltd. Bathroom Remodeling
111 River Elm, West St. Paul, MB R2V 4G2 2043345136, 2043389888