Jack Lin

Address:

321 Winter Walk Dr, Gaithersburg, MD 20878

VIN:

5FNRL38647B047374

Make:

HONDA

Model:

ODYSSEY

Year:

2007

US Patent:

7202266, Apr 10, 2007

Filed:

Jul 16, 2004

Appl. No.:

10/893134

Inventors:

James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US

Assignee:

Plexxikon, Inc. - Berkeley CA

International Classification:

A61K 209/08
C07D 209/08

US Classification:

514414, 514419, 548466, 548494

Abstract:

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

US Patent:

7348338, Mar 25, 2008

Filed:

Sep 8, 2004

Appl. No.:

10/937791

Inventors:

James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US

Assignee:

Plexxikon, Inc. - Berkeley CA

International Classification:

A61K 31/44
A61K 31/4725
A61K 31/404

US Classification:

514300, 514310, 514313, 514339, 514415

Abstract:

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

US Patent:

7572806, Aug 11, 2009

Filed:

Dec 7, 2007

Appl. No.:

12/001026

Inventors:

James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emerville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US

Assignee:

Plexxikon, Inc. - Berkeley CA

International Classification:

A61K 31/44
A61K 31/4725
A61K 31/404

US Classification:

514300, 514310, 514313, 514339, 514415

Abstract:

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

US Patent:

8367828, Feb 5, 2013

Filed:

Apr 28, 2010

Appl. No.:

12/768729

Inventors:

James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US

Assignee:

Plexxikon Inc. - Berkeley CA

International Classification:

C07D 471/04

US Classification:

546113, 546118

Abstract:

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

US Patent:

20110183988, Jul 28, 2011

Filed:

Dec 21, 2010

Appl. No.:

12/975239

Inventors:

Prabha N. Ibrahim - Mountain View CA, US
Guoxian Wu - Palo Alto CA, US
Jack Lin - Hercules CA, US
Wayne Spevak - Berkeley CA, US
Hanna Cho - Oakland CA, US
Todd Ewing - Walnut Creek CA, US
Chao Zhang - Moraga CA, US

International Classification:

A61K 31/498
C07D 471/04
A61K 31/437
A61K 31/506
A61K 31/513
A61K 31/497
A61P 35/00

US Classification:

514249, 546113, 514300, 544353, 544333, 514256, 544331, 514275, 544316, 514274, 544405, 51425505

Abstract:

Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.

US Patent:

20170349572, Dec 7, 2017

Filed:

Jun 12, 2017

Appl. No.:

15/620396

Inventors:

- Berkeley CA, US
Katrina Chan - Fremont CA, US
Todd Ewing - Walnut Creek CA, US
Prabha N. Ibrahim - Mountain View CA, US
Jack Lin - Hercules CA, US
Marika Nespi - Berkeley CA, US
Wayne Spevak - Berkeley CA, US
Ying Zhang - Fremont CA, US

International Classification:

C07D 401/12
C07F 5/02
C07D 513/04
C07D 487/04
C07D 403/12
A61K 31/437
A61K 31/675
A61K 31/5377
A61K 31/519
A61K 31/506
C07F 9/6561
C07D 471/04

Abstract:

Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

US Patent:

20150080372, Mar 19, 2015

Filed:

Oct 14, 2014

Appl. No.:

14/514232

Inventors:

- Berkeley CA, US
Guoxian Wu - Foster City CA, US
Jack Lin - Hercules CA, US
Wayne Spevak - Berkeley CA, US
Hanna Cho - Oakland CA, US
Todd Ewing - Walnut Creek CA, US
Chao Zhang - Moraga CA, US

International Classification:

C07D 471/04
A61K 31/519
A61K 31/498
A61K 31/497
A61K 31/437
A61K 31/506

US Classification:

51421021, 546113, 514300, 544316, 514274, 544353, 514249, 544333, 514269, 544405, 51425505, 546121, 544281, 51425941

Abstract:

Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.

US Patent:

20140213554, Jul 31, 2014

Filed:

Dec 20, 2013

Appl. No.:

14/137438

Inventors:

- Berkeley CA, US
Katrina Chan - Fremont CA, US
Todd Ewing - Walnut Creek CA, US
Prabha N. Ibrahim - Mountain View CA, US
Jack Lin - Hercules CA, US
Marika Nespi - Berkeley CA, US
Wayne Spevak - Berkeley CA, US
Ying Zhang - Fremont CA, US

International Classification:

C07D 401/12
A61K 31/437
C07F 5/02
C07D 487/04
C07D 513/04
C07D 403/12
A61K 31/506
A61K 31/5377
C07F 9/6561
A61K 31/675
C07D 471/04
A61K 31/519

US Classification:

514 81, 546113, 514300, 546 13, 544281, 5142593, 546118, 514303, 544331, 514275, 544127, 5142345, 546 23, 546114, 514301

Abstract:

Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.