Jacob A Joseph

US Patent:

6993377, Jan 31, 2006

Filed:

Feb 22, 2002

Appl. No.:

10/080421

Inventors:

James T. Flick - Little Rock AR, US
Jacob Joseph - Little Rock AR, US

Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

A61B 5/0452

US Classification:

600509

Abstract:

A method of analyzing electrocardiogram (EKG) data for use in the diagnosis of heart disease, prognosis of cardiac conditions, and the monitoring of heart disease therapies is disclosed. The method utilizes a wavelet-based multifractal analysis with one or more of (1) a discrete wavelet smoothing step to remove the effects of abnormal beats; (2) “Levy flight” analysis to detect the frequency of abnormal beats known to adversely affect the multifractal (MF) analysis; and (3) MF alpha analysis, a multifractal extension of monofractal short term (ST) alpha analysis. The invention further comprises an EKG test battery comprising Levy flight anomalous beat/beat cluster screening, followed by (ST) MF alpha analysis and MF Holder analysis (when validated by the Levy flight analysis). The wavelet smoothing step can also be used to classify human EKGs by observing the effect of sequential smoothing on the MF Holder coefficient. Alternative choices to the wavelet smoothing approach to removal of abnormal beat effects include probability distribution function analysis to determine the MF Holder coefficient directly, abnormal beat ridge skeleton removal to remove the offending beats based on a direct multifractal spectrum calculation, and the calculation of various types of entropy coefficients for the EKG time series.

US Patent:

20100204254, Aug 12, 2010

Filed:

Jan 29, 2010

Appl. No.:

12/657915

Inventors:

Martin K. Hauer-Jensen - Little Rock AR, US
Louis M. Fink - Little Rock AR, US
Jawahar Lal Mehta - Little Rock AR, US
Junru Wang - Little Rock AR, US
Jacob Joseph - Little Rock AR, US

Assignee:

The University of Arkansas for Medical Sciences - Little Rock AR

International Classification:

A61K 31/505
A61K 31/225
A61K 31/366
A61K 31/40
A61K 31/404

US Classification:

514275, 514548, 514460, 514423, 514419, 435375

Abstract:

The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the downregulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.