Jacob J Schlesinger

US Patent:

20100190147, Jul 29, 2010

Filed:

May 31, 2006

Appl. No.:

11/916149

Inventors:

Jacob J. Schlesinger - Pittsford NY, US
Xia Jin - Fairport NY, US
Robert C. Rose - Dansville NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

C12Q 1/70
C12N 15/13
C12N 5/00
C12M 1/00

US Classification:

435 5, 536 2353, 435325, 4352891

Abstract:

The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.

US Patent:

20110081317, Apr 7, 2011

Filed:

Aug 8, 2008

Appl. No.:

12/672386

Inventors:

Stephen Dewhurst - Rochester NY, US
Christine N. Zanghi - Rochester NY, US
Ketna Volcy - Rochester NY, US
Jacob J. Schlesinger - Pittsford NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 35/76
C12N 5/071
A61K 31/7088
C12N 15/63
A61P 37/04

US Classification:

424 932, 435325, 514 44 R, 4353201

Abstract:

Described herein are methods of improving the efficiency of gene transfer for a wide range of applications. Specifically provided are methods of increasing expression of an exogenous gene in a cell by contacting the cell with a vector comprising the exogenous gene and contacting the cell with a proteasome inhibitor, a lysosomal protease inhibitor and/or a microtubule inhibitor. Also provided are methods of delivering an antigen delivery vector to a cell or a subject. Provided are antigen delivery systems and kits comprising an antigen delivery vector and a proteasome inhibitor, a lysosomal protease and/or a microtuhulc inhibitor.

US Patent:

20130295162, Nov 7, 2013

Filed:

Oct 3, 2011

Appl. No.:

13/876893

Inventors:

Jacob J. Schlesinger - Pittsford NY, US
Xia Jin - Fairport NY, US
Robert C. Rose - Cleveland OH, US
Olivia K.T. Block - Rochester NY, US
W.W. Shanaka I. Rodrigo - Colombo, LK

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 39/12

US Classification:

424450, 4241861, 435 693

Abstract:

The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses.