James E Busby

US Patent:

7262280, Aug 28, 2007

Filed:

Oct 3, 2000

Appl. No.:

09/679664

Inventors:

Thomas M. Stormann - Salt Lake City UT, US
Lance G. Hammerland - Salt Lake City UT, US
Laura L. Storjohann - Salt Lake City UT, US
James G. Busby - Simi Valley CA, US
James E. Garrett - Salt Lake City UT, US
Rachel T. Simin - Durham NC, US

Assignee:

NPS Pharmaceuticals, Inc. - Salt Lake City UT

International Classification:

C07K 1/00
C08H 1/00
C07H 21/04
C12P 21/06
C12N 1/20

US Classification:

530402, 530350, 536 234, 536 235, 435 691, 4352523, 4353201, 435325, 435471

Abstract:

The present invention features G-protein fusion receptors and chimeric GABAreceptors (GABARs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from a CaR, an mGluR, and/or a GABAreceptor fused directly or through a linker to a guanine nucleotide-binding protein (G-protein). Chimeric GABARs comprise at least one of a GABAR extracellular domain, a GABAR transmembrane domain, or a GABAR intracellular domain and one or more domains from a mGluR subtype 8 (mGluR8) and/or a CaR.