James F Collawn

US Patent:

20020115824, Aug 22, 2002

Filed:

Nov 29, 2001

Appl. No.:

09/995804

Inventors:

Jeffrey Engler - Birmingham AL, US
Jae Lee - Seoul, KR
James Collawn - Birmingham AL, US
Bryan Moore - Palatine IL, US

International Classification:

C07K014/435
C07K007/06
C07K007/08

US Classification:

530/324000, 530/327000, 530/329000

Abstract:

Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.

US Patent:

20060193778, Aug 31, 2006

Filed:

Mar 23, 2004

Appl. No.:

10/806477

Inventors:

Jeffrey Engler - Birmingham AL, US
Jae Lee - Seoul, KR
James Collawn - Birmingham AL, US
Bryan Moore - Fishers IN, US

International Classification:

A61K 49/00
A61K 38/08
A61K 39/00

US Classification:

424009600, 514015000, 514016000, 424185100

Abstract:

Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.

US Patent:

20080166293, Jul 10, 2008

Filed:

Feb 18, 2008

Appl. No.:

12/032812

Inventors:

Jeffrey A. Engler - Birmingham AL, US
Jae Hwy Lee - Seoul, KR
James F. Collawn - Birmingham AL, US
Bryan A. Moore - Fishers IN, US

International Classification:

A61K 51/00
A61K 38/00
A61K 31/19
A61K 31/35
A61P 43/00
A61K 31/175
A61K 49/00

US Classification:

424 141, 514773, 514 2, 424 91, 424649, 514567, 514589, 514459, 514249, 424450

Abstract:

Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.

US Patent:

20140073632, Mar 13, 2014

Filed:

May 17, 2012

Appl. No.:

14/117705

Inventors:

Erik M. Schwiebert - Birmingham AL, US
James F. Collawn - Birmingham AL, US
Zsuzsa Bebok - Hoover AL, US

Assignee:

THE UAB RESEARCH FOUNDATION - Birmingham AL
DISCOVERYBIOMED INC. - Birmingham AL

International Classification:

C07D 513/04
C07D 473/06
C07D 223/04
C07D 417/04
C07D 251/46
C07D 241/52
C07D 487/04
C07D 239/42

US Classification:

51421711, 51425931, 51426334, 514275, 514363, 514342, 514245, 514249

Abstract:

Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.