James W Doherty

US Patent:

6809199, Oct 26, 2004

Filed:

Dec 17, 2001

Appl. No.:

10/023231

Inventors:

James B. Doherty - Montvale NJ
John E. Stelmach - Westfield NJ
Meng-Hsin Chen - Westfield NJ
Luping Liu - Lawrenceville NJ
Julianne A. Hunt - Scotch Plains NJ
Rowena D. Ruzck - Old Bridge NJ
Joung L. Goulet - Westfield NJ
David D. Wisnoski - Somerset NJ
Swaminathan Ravi Natarajan - Edison NJ
Kathleen M. Rupprecht - Cranford NJ
Jianming Bao - Scotch Plains NJ
Shouwu Miao - Edison NJ
Xingfang Hong - Westfield NJ
Peter J. Sinclair - Scotch Plains NJ
Florida Kallashi - Yonkers NY

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D23972

US Classification:

544256, 546122

Abstract:

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.

US Patent:

7163134, Jan 16, 2007

Filed:

Jan 3, 2005

Appl. No.:

11/028450

Inventors:

Larry M. Moeller - Mundelein IL, US
Joseph E. Fabin - Elmwood Park IL, US
James E. Doherty - Barrington IL, US

Assignee:

Illinois Tool Works Inc. - Glenview IL

International Classification:

B25C 1/04

US Classification:

227 8, 227 2, 227 10, 227130

Abstract:

A combustion-powered fastener-driving tool includes a combustion-powered power source, a workpiece contact element reciprocable relative to the power source between a rest position and a firing position, a control system operationally associated with the power source, a trigger connected to the control system providing operator interface with the control system. The control system is configured so that an operator may select between a sequential firing mode in which the trigger must be released between firings, and a repetitive cycle mode in which the trigger is continually depressed between firings. The trigger is connected to the control system so that at least one of the frequency and duration of pulling of the trigger converts the operating mode from the sequential mode to the repetitive cycle mode.

US Patent:

7196082, Mar 27, 2007

Filed:

Oct 14, 2003

Appl. No.:

10/684990

Inventors:

James B. Doherty - Montvale NJ, US
Meng-Hsin Chen - Westfield NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/5375
A61K 31/44
A61K 31/416
C07D 231/56
C07D 413/06

US Classification:

5142352, 544106, 544111, 544132, 544140, 5462681, 5462757, 5483561, 5483611, 5483625, 5142312, 5142335, 514339, 514406

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

7196095, Mar 27, 2007

Filed:

Jun 21, 2002

Appl. No.:

10/477367

Inventors:

Tesfaye Biftu - Westfield NJ, US
Richard Beresis - Matawan NJ, US
Richard Berger - Cranford NJ, US
Steven L. Colletti - Princeton Junction NJ, US
James B. Doherty - Montvale NJ, US
Dennis D. Feng - Branchburg Township NJ, US
Dennis M. Schmatz - Cranford NJ, US
Xiaoxia Qian - New York NY, US
David A. Claremon - Maple Glen PA, US
Nigel J. Liverton - Harleysville PA, US
Charles J. McIntyre - Lansdale PA, US
Ernest W. Kovacs - Weehawken NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 403/04
C07D 403/14
C07D 417/04
C07D 417/14
A61K 31/506
A61P 19/02

US Classification:

514275, 514243, 5142591, 544331, 544184, 544281

Abstract:

Compounds of formula (I) and pharmaceutically acceptable salts thereof are useful in the treatment of cytokine mediated diseases such as arthritis and in the treatment and/or prevention of protozoal diseases such as coccidiosis.

US Patent:

7201301, Apr 10, 2007

Filed:

Jan 3, 2005

Appl. No.:

11/028023

Inventors:

Larry M. Moeller - Mundelein IL, US
James E. Doherty - Mount Prospect IL, US

Assignee:

Illinois Tool Works Inc. - Glenview IL

International Classification:

B25C 1/04

US Classification:

227 8, 227 10, 227130, 123 46 SC

Abstract:

A combustion-powered fastener-driving tool includes a combustion-powered power source including a cylinder defining a path for a reciprocating piston and an attached driver blade, the piston reciprocating between a pre-firing position achieved prior to combustion and a bottom out position. Upon combustion in the power source, the cylinder includes at least one exhaust valve configured for releasing combustion gases from the cylinder. The at least one exhaust valve is dimensioned so that sufficient gas is released to reduce post-combustion pressure in the cylinder to approximately one atmosphere in the time available for the piston to travel past the at least one exhaust valve and return to the at least one exhaust valve.

US Patent:

7314873, Jan 1, 2008

Filed:

Jun 6, 2003

Appl. No.:

10/517754

Inventors:

James B. Doherty - Montvale NJ, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
John E. Stelmach - Westfield NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/5377
A61K 31/491
A61K 31/519
C07D 413/14
C07D 471/14
C07D 487/14
C07D 213/26
C07D 213/30

US Classification:

5142345, 5142641, 51425214, 544279, 544117, 546303, 546334

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

US Patent:

7341171, Mar 11, 2008

Filed:

Jan 3, 2005

Appl. No.:

11/028020

Inventors:

Larry M. Moeller - Mundelein IL, US
Joseph E. Fabin - Elmwood Park IL, US
James E. Doherty - Mount Prospect IL, US
Yury Shkolnikov - Glenview IL, US

Assignee:

Illinois Tool Works Inc. - Glenview IL

International Classification:

F02B 71/00

US Classification:

227 8, 227 10, 227130, 123 46 SC, 123 46 R

Abstract:

A combustion-powered fastener-driving tool includes a combustion-powered power source, at least one fan for associated with the power source, at least one temperature sensing device in operational proximity to the power source and a control system operationally associated with the power source and connected to the at least one fan and at least one temperature sensing device for adjusting the length of time for energizing the at least one cooling fan as a function of power source temperature sensed by the at least one temperature sensing device.

US Patent:

7383974, Jun 10, 2008

Filed:

Aug 9, 2006

Appl. No.:

11/501316

Inventors:

Larry M. Moeller - Mundelein IL, US
James E. Doherty - Mount Prospect IL, US
Joseph E. Fabin - Elmwood Park IL, US

Assignee:

Illinois Tool Works Inc. - Glenview IL

International Classification:

B25C 1/04

US Classification:

227 8, 227 10, 227130, 123 46 SC

Abstract:

A combustion-powered fastener-driving tool includes a combustion-powered power source, a valve sleeve reciprocable relative to the power source between a rest position and a firing position, and a lockout device in operational proximity to the valve sleeve and configured for automatically preventing the reciprocation of the valve sleeve from the firing position until a piston in the power source returns to a pre-firing position.