James E Foy

US Patent:

7683200, Mar 23, 2010

Filed:

Jun 30, 2006

Appl. No.:

11/477936

Inventors:

Francis G. Fang - Andover MA, US
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Andre Lescarbeau - Sommerville MA, US
Xiang Nu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R & D Management Co., Ltd. - Tokyo

International Classification:

C07F 9/02

US Classification:

558166, 558172

Abstract:

The present invention provides methods for preparing TLR-4 receptor agonist E6020:and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.

US Patent:

7919643, Apr 5, 2011

Filed:

Dec 18, 2008

Appl. No.:

12/338517

Inventors:

Bruce DeCosta - Salem NH, US
Francis G. Fang - Andover MA, US
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Xiang Niu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R & D Management Co., Ltd.

International Classification:

C07F 9/02

US Classification:

558114, 558171

Abstract:

This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation.

US Patent:

8049023, Nov 1, 2011

Filed:

Nov 15, 2010

Appl. No.:

12/945959

Inventors:

Bruce DeCosta - Salem NH, US
Francis G. Fang - Andover MA, US
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Xiang Niu - Watertown MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R&D Management Co., Ltd. - Tokyo

International Classification:

C07C 229/00

US Classification:

554109

Abstract:

This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation.

US Patent:

8198474, Jun 12, 2012

Filed:

Feb 2, 2010

Appl. No.:

12/698686

Inventors:

Francis G. Fang - Andover MA, US
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Andre Lescarbeau - Sommerville MA, US
Xiang Niu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R&D Management Co., Ltd.

International Classification:

C07F 9/02

US Classification:

558171, 558172

Abstract:

The present invention provides methods for preparing TLR-4 receptor agonist E6020:and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates useful for implementing the inventive methods.

US Patent:

8519170, Aug 27, 2013

Filed:

May 10, 2012

Appl. No.:

13/468634

Inventors:

Francis G. Fang - Andover MA, US
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Andre Lescarbeau - Sommerville MA, US
Xiang Niu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R&D Management Co., Ltd.

International Classification:

C07C 229/00

US Classification:

554110, 554109

Abstract:

The present invention provides methods for preparing TLR-4 receptor agonist E6020:.

US Patent:

20140012011, Jan 9, 2014

Filed:

Jul 22, 2013

Appl. No.:

13/947593

Inventors:

- Tokyo, JP
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Andre LesCarbeau - Sommerville MA, US
Xiang Niu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R&D Management Co., Ltd. - Tokyo

International Classification:

C07D 263/14

US Classification:

548239

Abstract:

The present invention provides methods for preparing TLR-4 receptor agonist E6020:

US Patent:

6479660, Nov 12, 2002

Filed:

Dec 14, 2001

Appl. No.:

09/051571

Inventors:

Cletus Onwuzurike Ugwuegbulam - Stevenage, GB
James Edward Foy - Dresher PA

Assignee:

SmithKline Beecham p.l.c. - Brentford
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D21516

US Classification:

546153, 514312

Abstract:

The invention relates to novel intermediates and processes for the preparation of quinoline compounds useful as anti-malarial drugs and novel intermediates useful in the process. A process for the preparation of a compound of formula (I) in which R is C alkyl; R and R are independently hydrogen, halogen, trifluoromethyl or C alkoxy; R is C alkyl; R is hydrogen or C alkyl; and R or amino which comprises reacting a compound of formula (II) in which R , R and R are as defined in formula (I) and X is a leading group with a compound of formula (III).

US Patent:

20140323739, Oct 30, 2014

Filed:

May 5, 2014

Appl. No.:

14/269659

Inventors:

- Tokyo, JP
James E. Foy - Andover MA, US
Lynn Hawkins - Concord MA, US
Charles Lemelin - North Chelmsford MA, US
Andre LesCarbeau - Sommerville MA, US
Xiang Niu - Malden MA, US
Kuo-Ming Wu - Acton MA, US

Assignee:

Eisai R&D Management Co.. Ltd. - Tokyo

International Classification:

C07D 263/14

US Classification:

548239

Abstract:

The present invention provides methods for preparing TLR-4 receptor agonist E6020:and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.

Address:

864 Wayside Ln, Haddonfield, NJ 08033

VIN:

JHLRE48717C002093

Make:

HONDA

Model:

CR-V

Year:

2007