James Robin French

US Patent:

47710705, Sep 13, 1988

Filed:

Sep 26, 1986

Appl. No.:

6/912684

Inventors:

Gerard C. Hokanson - Ann Arbor MI
John P. Schaumberg - Ypsilanti MI
James C. French - Ann Arbor MI
Josefino B. Tunac - Troy MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31365
C07D30938

US Classification:

514460

Abstract:

A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties. The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound. The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

US Patent:

46613536, Apr 28, 1987

Filed:

Dec 4, 1985

Appl. No.:

6/804411

Inventors:

John H. Wilton - Ann Arbor MI
Gerard C. Hokanson - Ann Arbor MI
James C. French - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3574
C12P 106

US Classification:

424123

Abstract:

CL-1577-B. sub. 4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions. CL-1577-B. sub. 4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line. A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.

US Patent:

46804161, Jul 14, 1987

Filed:

Jul 16, 1985

Appl. No.:

6/755389

Inventors:

Gerard C. Hokanson - Ann Arbor MI
Richard H. Bunge - Ann Arbor MI
Timothy R. Hurley - Ann Arbor MI
James C. French - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D30932

US Classification:

549292

Abstract:

Novel pyranone compounds and related compounds, methods of preparing the compounds, and their use as cytotoxic and/or antileukemic agents or precursors, are provided.

US Patent:

44631820, Jul 31, 1984

Filed:

Jun 26, 1978

Appl. No.:

5/919023

Inventors:

William G. Freckman - Mt. Clemens MI
Zbigniew L. Jakubowski - St. Clair Shores MI
Richard H. Bunge - Mt. Clemens MI
James C. French - Ann Arbor MI
Lucia E. Balta - Harper Woods MI

Assignee:

Warner-Lambert Company - Ann Arbor MI

International Classification:

C07D49320

US Classification:

549264

Abstract:

The present invention relates to roridin E-2 which is represented by Formula I and a process for the production of said compound. ##STR1##.

US Patent:

40310698, Jun 21, 1977

Filed:

Mar 1, 1976

Appl. No.:

5/662381

Inventors:

Ernest D. Nicolaides - Ann Arbor MI
Francis John Tinney - Ann Arbor MI
James Clark French - Ann Arbor MI

Assignee:

Parke, Davis & Company - Detroit MI

International Classification:

C07C10352

US Classification:

2601125LH

Abstract:

New tetrapeptides having the formula A-R. sub. 1 -Ser(benzyl)-Tyr(benzyl)-R. sub. 2 -R. sub. 3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R. sub. 1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); R. sub. 2 is D-Ala,. beta. -Ala, D-Leu or D-Val; and R. sub. 3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

US Patent:

46967940, Sep 29, 1987

Filed:

Nov 7, 1986

Appl. No.:

6/928443

Inventors:

Richard H. Bunge - Ann Arbor MI
James C. French - Ann Arbor MI
Timothy R. Hurley - Ann Arbor MI
Neil E. Willmer - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3574
C12D 106

US Classification:

424118

Abstract:

A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957D. The antimicrobial compound CL-1957D is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957D compound is produced, and subsequently isolating the CL-1957D compound. The antibiotic compound CL-1957D and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections in mammals, employing these pharmaceutical compositions.

US Patent:

45308357, Jul 23, 1985

Filed:

Jul 8, 1983

Appl. No.:

6/512088

Inventors:

Richard H. Bunge - Ann Arbor MI
James C. French - Ann Arbor MI
Timothy R. Hurley - Ann Arbor MI
Tim A. Smitka - Ann Arbor MI
Josefino B. Tunac - Troy MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61R 3574
C12P 106

US Classification:

424117

Abstract:

A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors. Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds. The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.

US Patent:

54630355, Oct 31, 1995

Filed:

Feb 28, 1995

Appl. No.:

8/396443

Inventors:

James C. French - Ann Arbor MI
Colin R. Edmunds - Abergavenny, GB
Peter McDonnell - Caerleon Gwent, GB
Howard D. H. Showalter - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07H 1923
C07H 1904

US Classification:

536 553

Abstract:

A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated eluate to a strongly basic anion exchange resin charged with borate ion; 5) eluting with water; 6) applying this eluate to styrene-divinylbenzene beads prewashed with ethanol; 7) eluting the beads with water; and 8) recrysllyzing the pentostatin from water and methanol to yield a product that is greater than 99. 7% pure.