James W Hecker

US Patent:

20110111439, May 12, 2011

Filed:

Oct 7, 2010

Appl. No.:

12/899833

Inventors:

James G. Hecker - Media PA, US
Michael Lee McGarvey - Philadelphia PA, US

International Classification:

G01N 33/53
G01N 33/566
C07K 14/47

US Classification:

435 792, 436501, 530350

Abstract:

Provided are methods for intra-operatively predicting, detecting or diagnosing the risk or onset of spinal cord ischemia and/or associated permanent paralysis in a patient, based upon the stress-induced elevation of levels of heat shock proteins, specifically HSP70 and/or HSP27 in the cerebral spinal fluid of the patient, as measured during thoracic-aorta surgery, particularly thoracic aneurysm repair surgery, that will permit intra-operative medical intervention to try to prevent or attenuate severe, and often fatal, complications. Further provided are kits, assay devices and methods of analyzing biomarker data for use in pre-, intra- or post-operatively detecting the stress-induced elevations of the measured levels of HSP70 and/or HSP27, and the biomarker itself.

US Patent:

20100249208, Sep 30, 2010

Filed:

Dec 14, 2006

Appl. No.:

12/086605

Inventors:

James G Hecker - Media PA, US
Micheal Nantz - Louisville KY, US

International Classification:

A61K 31/7088
A61P 25/28
A61P 25/16
A61P 25/00
C12N 15/64
C12N 5/02

US Classification:

514 44 A, 514 44 R, 4353201, 435375

Abstract:

Provided are safe, non-invasive, non-viral delivery methods for providing a nucleic acid into the neuronal and non-neuronal cells of the central nervous system (CNS) of a subject to protect neuronal and non-neuronal cells from ischemic or traumatic injury, wherein the nucleic acid encodes a therapeutic proteins, specifically providing rapid transient expression and widespread distribution for in vitro or in vivo applications. Further provided are methods for the intrathecal delivery to the cerebrospinal fluid (CSF) of a neuroprotective gene sequence, e.g., a heat shock protein (HSP), complexed with cationic lipid compositions to achieve such delivery, and the complexes used therein.