James R Hendricks

US Patent:

20210162048, Jun 3, 2021

Filed:

Nov 6, 2020

Appl. No.:

17/091863

Inventors:

- Boston MA, US
Balaram Ghosh - Boston MA, US
James Adam Hendricks - Watertown MA, US
Surya Reis - Boston MA, US
Stephen John Haggarty - Dorchester MA, US

International Classification:

A61K 41/00
C07D 333/20
C07D 409/14
C07D 491/16
C07F 5/02
C07C 259/06
C07C 245/08
C07C 259/10

Abstract:

This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.

US Patent:

20190070295, Mar 7, 2019

Filed:

May 1, 2018

Appl. No.:

15/968634

Inventors:

- Boston MA, US
Balaram Ghosh - Boston MA, US
James Adam Hendricks - Watertown MA, US
Surya Reis - Boston MA, US
Stephen John Haggarty - Dorchester MA, US

International Classification:

A61K 41/00
C07C 259/10
C07C 245/08
C07D 333/20
C07F 5/02
C07D 491/16
C07D 409/14
C07C 259/06

Abstract:

This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.

US Patent:

20160022817, Jan 28, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/775340

Inventors:

- Boston MA, US
Balaram Ghosh - Boston MA, US
James Adam Hendricks - Watertown MA, US
Surya Reis - Boston MA, US
Stephen John Haggarty - Dorchester MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 41/00
C07C 259/10
C07C 259/06

Abstract:

This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.