James G Hogan

US Patent:

6376186, Apr 23, 2002

Filed:

May 3, 2000

Appl. No.:

09/565241

Inventors:

James J. Hogan - Coronado CA
Patricia Gordon - San Diego CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 168

US Classification:

435 6, 536 237, 536 2432, 435810

Abstract:

Polynucleotide probes and accessory helper oligonucleotides useful for detecting bacteria that are members of the genus Staphylococcus. The hybridization probes are highly specific for Staphylococcal bacteria and do not cross-hybridize with the rRNA or rDNA of numerous other bacterial and fungal species.

US Patent:

6495327, Dec 17, 2002

Filed:

May 1, 2001

Appl. No.:

09/847842

Inventors:

Curt L. Milliman - St. Louis MO
Gary G. Bee - Vista CA
James J. Hogan - Coronado CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 168

US Classification:

435 6, 536 2374, 536 2432

Abstract:

Hybridization assay probes and accessory oligonucleotides for detecting ribosomal nucleic acids from and/or.

US Patent:

6512105, Jan 28, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/609475

Inventors:

James John Hogan - San Diego CA
Richard Dana Smith - San Diego CA
Jo Ann Kop - San Marcos CA
Sherrol Hoffa McDonough - San Diego CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 2100

US Classification:

536 243, 435 6, 436501, 536 231, 536 2431, 536 2432, 536 253, 702 20

Abstract:

A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to be unique to a non-viral organism or group of non-viral organisms sought to be detected, said region of rRNA being selected by comparing one or more variable region rRNA sequences of said non-viral organism or group of non-viral organisms with one or more variable region rRNA sequences from one or more non-viral organisms sought to be distinguished. Hybridization assay probes for , the -complex bacteria, , Legionella, Salmonella, , Campylobacter, , Enterococcus, , Pseudomonas group I, , bacteria, and fungi also are disclosed.

US Patent:

6773882, Aug 10, 2004

Filed:

May 1, 2001

Appl. No.:

09/846797

Inventors:

James J. Hogan - Coronado CA
Patricia C. Gordon - Spring Valley CA

Assignee:

Gen-Probe, Incorporated - San Diego CA

International Classification:

C12Q 168

US Classification:

435 6, 435471, 536 231

Abstract:

Hybridization probes and accessory oligonucleotides useful for detecting ribosomal nucleic acids from and with high specificity.

US Patent:

6821770, Nov 23, 2004

Filed:

May 3, 2000

Appl. No.:

09/565238

Inventors:

James J. Hogan - Coronado CA

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 2104

US Classification:

4352872, 435 6, 435 911, 435 912, 536 231, 536 243

Abstract:

Method of identifying microbial organisms wherein a biological sample containing nucleic acids is hybridized with a collection of polynucleotide probes, each probe having binding specificity for the ribosomal nucleic acids of at least one microbe. The collection of probes is organized into a series of âaddressesâ that provide information about the presence or absence of one or more polynucleotide sequences in the biological sample. Probes in the matrix are selected to distinguish between organisms that differ from each other by a known phylogenetic relationship. Advantageously, the invented method can detect and resolve the identities of microorganisms that are present in a mixed culture. The system is particularly suited to automated analysis.

US Patent:

7087742, Aug 8, 2006

Filed:

May 31, 1995

Appl. No.:

08/455977

Inventors:

James John Hogan - Coronado CA, US
Richard Dana Smith - Victoria, CA
JoAnn Kop - Fremont CA, US
Sherrol Hoffa McDonough - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68

US Classification:

536 243, 536 2432, 536 253, 435 6

Abstract:

A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to be unique to a non-viral organism or group of non-viral organisms sought to be detected, said region of rRNA being selected by comparing one or more variable region rRNA sequences of said non-viral organism or group of non-viral organisms with one or more variable region rRNA sequences from one or more non-viral organisms sought to be distinguished. Hybridization assay probes for , the -complex bacteria, group I, , bacteria, and fungi also are disclosed.

US Patent:

7090972, Aug 15, 2006

Filed:

May 30, 1995

Appl. No.:

08/454529

Inventors:

James John Hogan - Coronado CA, US
Richard Dana Smith - Victoria, CA
JoAnn Kop - Fremont CA, US
Sherrol Hoffa McDonough - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 243, 536 2432, 536 253

Abstract:

A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to be unique to a non-viral organism or group of non-viral organisms sought to be detected, said region of rRNA being selected by comparing one or more variable region rRNA sequences of said non-viral organism or group of non-viral organisms with one or more variable region rRNA sequences from one or more non-viral organisms sought to be distinguished. Hybridization assay probes for , the -complex bacteria, group I, , bacteria, and fungi also are disclosed.

US Patent:

7138516, Nov 21, 2006

Filed:

May 30, 1995

Appl. No.:

08/454064

Inventors:

James John Hogan - San Diego CA, US
Richard Dana Smith - San Diego CA, US
Jo Ann Kop - San Marcos CA, US
Sherrol Hoffa McDonough - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68

US Classification:

536 243, 536 2432, 536 253, 435 6

Abstract:

A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to be unique to a non-viral organism or group of non-viral organisms sought to be detected, said region of rRNA being selected by comparing one or more variable region rRNA sequences of said non-viral organism or group of non-viral organisms with one or more variable region rRNA sequences from one or more non-viral organisms sought to be distinguished. Hybridization assay probes for , the -complex bacteria, group I, , bacteria, and fungi also are disclosed.