James E Lipscomb

US Patent:

6604054, Aug 5, 2003

Filed:

Feb 28, 2001

Appl. No.:

09/794255

Inventors:

James H. Lipscomb - Kennett Square PA
Larry Jurik - late of Elmhurst IL
Bernard Katz - Rockaway NJ
Michael J. Keating - Blairstown NJ
Stone Klengler - Escondido CA
John J. Kotlarik - Lake Geneva WI
Mieczyslaw Wroblewski - Lake Forest IL

Assignee:

Gen-Probe, Inc. - San Diego CA

International Classification:

G01F 15075

US Classification:

702 47, 7386142, 7386144, 138104, 324647, 417 63

Abstract:

A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.

US Patent:

6658946, Dec 9, 2003

Filed:

Aug 8, 2002

Appl. No.:

10/214161

Inventors:

James H. Lipscomb - Kennett Square PA
Larry Jurik - late of Elmhurst IL
Bernard Katz - Rockaway NJ
Michael J. Keating - Blairstown NJ
Stone Klengler - Escondido CA
John J. Kotlarik - Lake Geneva WI
Mieczyslaw Wroblewski - Lake Forest IL

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

G01F 2202

US Classification:

7386142, 7386144, 702 47

Abstract:

A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant device for detecting fluid flow through the conduit.

US Patent:

6663353, Dec 16, 2003

Filed:

Aug 8, 2002

Appl. No.:

10/214158

Inventors:

James H. Lipscomb - Kennett Square PA
Larry Jurik - late of Elmhurst IL
Bernard Katz - Rockaway NJ
Michael J. Keating - Blairstown NJ
Stone Klengler - Escondido CA
John J. Kotlarik - Lake Geneva WI
Mieczyslaw Wroblewski - Lake Forest IL

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

G01F 2202

US Classification:

417 63, 7386422, 7386425

Abstract:

A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.

US Patent:

6851453, Feb 8, 2005

Filed:

Apr 30, 2003

Appl. No.:

10/425615

Inventors:

James H. Lipscomb - Kennett Square PA, US
Anna Jurik - Elmhurst IL, US
Bernard Katz - Rockaway NJ, US
Michael J. Keating - Blairstown NJ, US
Stone Klengler - Escondido CA, US
John J. Kotlarik - Lake Geneva WI, US
Mieczyslaw Wroblewski - Lake Forest IL, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

F16L055/00
F16L009/22
G01F001/56
B01L003/02

US Classification:

138104, 137557, 138177, 7386473, 7386425, 324647

Abstract:

A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.

US Patent:

6914555, Jul 5, 2005

Filed:

May 1, 2003

Appl. No.:

10/426655

Inventors:

James H. Lipscomb - Kennett Square PA, US
Anna Jurik - Elmhurst IL, US
Bernard Katz - Rockaway NJ, US
Michael J. Keating - Blairstown NJ, US
Stone Klengler - Escondido CA, US
John J. Kotlarik - Lake Geneva WI, US
Mieczyslaw Wroblewski - Lake Forest IL, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

G01F023/284

US Classification:

342124, 324647, 73290 R

Abstract:

A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.

US Patent:

8524490, Sep 3, 2013

Filed:

Sep 16, 2009

Appl. No.:

12/561092

Inventors:

James H. Lipscomb - Kennett Square PA, US
Peter Blacklin - Columbia MD, US
Michael Keating - Hardwick NJ, US
Robert Bernstine - Chesapeake City MD, US
Richard Raffauf, Jr. - Reading PA, US

Assignee:

X-Bar Diagnostic Systems, Inc. - Kennett Square PA

International Classification:

C12M 1/00
C12M 1/36
C12M 1/38

US Classification:

4353031, 4352862, 4352872, 4352873, 435809

Abstract:

Provided herein is a portable thermocycler, comprising: (i) a case; (ii) a rotary plate in the case; (iii) a plurality of heating blocks arranged in a geometric pattern disposed on the rotary plate; and (iv) at least one vessel adapted to move and contact at least two of the plurality of heating blocks; wherein each of the heating blocks comprises a heating plate maintained at a set temperature over a thermally insulating material; wherein the geometric pattern comprises a number of center heating blocks arranged in a shape defining a polygon and a number of outside heating blocks disposed around the periphery of the rotary plate; and wherein the rotary plate includes a plurality of rotating wheels adapted to rotate at least one of the vessels into contact with each of the heating blocks.

US Patent:

52326659, Aug 3, 1993

Filed:

Jul 26, 1991

Appl. No.:

7/736157

Inventors:

Robert A. Burkovich - Newark DE
James H. Lipscomb - Kennett Square PA
Colin A. Nurse - Newark DE
Kin W. Wong - Claymont DE
Paul J. Zuk - Lincoln University PA
Robert E. Bernstine - Chesapeake City MD

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

G01N 3300
C12M 100
C12M 140

US Classification:

422 65

Abstract:

The apparatus processes immunoassays of samples using a solid support. It provides a compact system using rectilinear motion to process carriers holding samples on a real time basis while permitting the input and output of the system to operate on a random basis.

US Patent:

52169260, Jun 8, 1993

Filed:

Aug 5, 1992

Appl. No.:

7/924636

Inventors:

James H. Lipscomb - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

G01N 3506

US Classification:

7386425

Abstract:

An automatic sampling apparatus is constructed to use bang-bang fluid driven actuators whose control system is modified to permit accurate positioning over its range of motion. The actuators are positioned to aspirate liquid contents held within stoppered sample containers and equilibrate pressure in the sample containers to atmospheric prior to aspiration.