James Larry Little

US Patent:

7510536, Mar 31, 2009

Filed:

Dec 16, 2004

Appl. No.:

11/016701

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61H 1/00
A61B 8/00

US Classification:

601 2, 600439

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

8197409, Jun 12, 2012

Filed:

Feb 23, 2009

Appl. No.:

12/390975

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 8/00
A61H 1/00

US Classification:

600439, 601 2

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

8211017, Jul 3, 2012

Filed:

Sep 21, 2010

Appl. No.:

12/887178

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 8/00
A61H 1/00

US Classification:

600439, 601 2

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

8206299, Jun 26, 2012

Filed:

Sep 21, 2010

Appl. No.:

12/887211

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 8/00
A61H 1/00

US Classification:

600439, 601 2

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

20110040171, Feb 17, 2011

Filed:

Sep 21, 2010

Appl. No.:

12/887232

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 5/055
A61N 7/00

US Classification:

600411

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

20120316426, Dec 13, 2012

Filed:

Aug 20, 2012

Appl. No.:

13/590146

Inventors:

Jessica L. Foley - Seattle WA, US
Shahram Vaezy - Seattle WA, US
James W. Little - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61N 7/02
A61B 5/055
A61B 8/12
A61B 8/13

US Classification:

600411, 600439

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

US Patent:

D3748545, Oct 22, 1996

Filed:

Sep 11, 1995

Appl. No.:

D/043692

Inventors:

James E. Little - Seattle WA
Narcisa T. Little - Seattle WA

US Classification:

D12400

US Patent:

20140094682, Apr 3, 2014

Filed:

Dec 3, 2013

Appl. No.:

14/095986

Inventors:

- Seattle WA, US
Shahram Vaezy - Seattle WA, US
James Little - Seattle WA, US

Assignee:

University of Washington, Center for Commercialization - Seattle WA

International Classification:

A61B 8/13
A61B 17/32
A61B 5/00

US Classification:

600411, 600437, 600443, 600439

Abstract:

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.