James Christopher Loyd

US Patent:

6642002, Nov 4, 2003

Filed:

Jul 17, 2001

Appl. No.:

09/908500

Inventors:

James E. Loyd - Nashville TN
Kirk B. Lane - Brentwood TN
Richard C. Trembath - Rutland, GB
Rajiv D. Machado - Leicester, GB
Jennifer R. Thomson - Leeds, GB
William C. Nichols - Loveland OH
Michael W. Pauciulo - Blue Ash OH
Tatiana Foroud - Indianapolis IN

Assignee:

Vanderbilt University - Nashville TN
Advanced Research Technology Institute - Indianapolis ID
Childrens Hospital Medical Center - Cincinnati OH
University of Leicester - Leicester

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 235, 536 2431, 536 2433

Abstract:

This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.

US Patent:

6756033, Jun 29, 2004

Filed:

Aug 6, 2002

Appl. No.:

10/212149

Inventors:

Gilles Cloutier - Chapel Hill NC
James Crow - Chapel Hill NC
Michael Wade - Chapel Hill NC
Richard E. Parker - Spring Hill TN
James E. Loyd - Nashville TN

Assignee:

United Therapeutics Corporation - Washington DC

International Classification:

A61K 912

US Classification:

424 45, 424 46, 424489, 514571, 514573, 560 56

Abstract:

A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.

US Patent:

7195016, Mar 27, 2007

Filed:

Jan 7, 2004

Appl. No.:

10/752936

Inventors:

James Loyd - Nashville TN, US
Dennis Creedon - Sandwich MA, US
Lewis H. Marten - Westwood MA, US

Assignee:

E. Benson Hood Laboratories - Pembroke MA

International Classification:

A61M 16/00

US Classification:

12820714, 12820026, 12820024

Abstract:

An apparatus and method for implanting a surgical apparatus including a first flange having an opening, a second flange having an opening, and a shaft having a lumen connecting the first and second flange openings. The surgical apparatus is inserted into a stoma formed in the trachea of a patient. The surgical apparatus receives and secures an oxygen supply line for patients who have difficulty breathing.

US Patent:

20040023280, Feb 5, 2004

Filed:

Jun 6, 2003

Appl. No.:

10/457030

Inventors:

James Loyd - Nashville TN, US
Kirk Lane - Brentwood TN, US
John Phillips - Brentwood TN, US
Richard Trembath - Oakham, GB
Rajiv Machado - Leicester, GB
Jennifer Thomson - Leeds, GB
William Nichols - Loveland OH, US
Michael Pauciulo - Blue Ash OH, US
Tatiana Foroud - Indianapolis IN, US

International Classification:

C12Q001/68
G01N033/53

US Classification:

435/006000, 435/007100

Abstract:

This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.

US Patent:

20060157061, Jul 20, 2006

Filed:

Feb 21, 2006

Appl. No.:

11/358469

Inventors:

James Loyd - Nashville TN, US
Dennis Creedon - Sandwich MA, US
Lewis Marten - Westwood MA, US

International Classification:

A62B 9/06
A61M 16/00

US Classification:

128207140, 128207150, 128207160

Abstract:

An apparatus and method for implanting a surgical apparatus including a first flange having an opening, a substantially X-shaped second flange having an opening, and a shaft having a lumen connecting the first and second flange openings. The surgical apparatus is inserted into a stoma formed in the trachea of a patient. The surgical apparatus receives and secures an oxygen supply line for patients who have difficulty breathing.

US Patent:

20090124697, May 14, 2009

Filed:

Sep 19, 2008

Appl. No.:

12/232611

Inventors:

Gilles Cloutier - Chapel Hill NC, US
James Crow - Chapel Hill NC, US
Michael Wade - Chapel Hill NC, US
Richard E. Parker - Spring Hill TN, US
James E. Loyd - Nashville TN, US

International Classification:

A61K 31/192

US Classification:

514569

Abstract:

The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

US Patent:

6521212, Feb 18, 2003

Filed:

Mar 15, 2000

Appl. No.:

09/525471

Inventors:

Gilles Cloutier - Chapel Hill NC
James Crow - Chapel Hill NC
Michael Wade - Chapel Hill NC
Richard E. Parker - Spring Hill TN
James E. Loyd - Nashville TN

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 912

US Classification:

424 45, 424 46, 424489, 514573, 514571

Abstract:

A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.

US Patent:

20150164834, Jun 18, 2015

Filed:

Feb 24, 2015

Appl. No.:

14/629938

Inventors:

- Silver Spring MD, US
James Crow - Chapel Hill NC, US
Michael Wade - Chapel Hill NC, US
Richard E. Parker - Spring Hill TN, US
James E. Loyd - Nashville TN, US

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/192

Abstract:

The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.