James Matson

US Patent:

6780620, Aug 24, 2004

Filed:

Dec 21, 1999

Appl. No.:

09/468854

Inventors:

Wenying Li - Middletown CT
James A. Matson - Cheshire CT
Xiaohua Huang - Wallingford CT
Kin Sing Lam - North Haven CT
Grace A. McClure - Northford CT

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1700

US Classification:

435117, 435118, 435119, 435121, 435123

Abstract:

A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.

US Patent:

7244594, Jul 17, 2007

Filed:

Mar 23, 2004

Appl. No.:

10/807089

Inventors:

Wenying Li - Middletown CT, US
James A. Matson - Cheshire CT, US
Xiaohua Huang - Wallingford CT, US
Kin Sing Lam - North Haven CT, US
Grace A. McClure - Northford CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 17/08
C12P 17/02
C12P 17/10
C12P 17/00
C12P 17/14

US Classification:

435117, 435 711, 435118, 435119, 435120, 514183, 514365, 514450, 540451, 540455, 540462, 548204, 549269

Abstract:

A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.

US Patent:

D684655, Jun 18, 2013

Filed:

Nov 15, 2012

Appl. No.:

29/437313

Inventors:

James Fred Matson - Pottstown PA, US

International Classification:

2205

US Classification:

D22129

US Patent:

50011120, Mar 19, 1991

Filed:

Mar 17, 1989

Appl. No.:

7/323001

Inventors:

Sandra J. Hofstead - Middletown CT
James A. Matson - Cheshire CT
Kin S. Lam - Cheshire CT
Salvatore Forenza - Cheshire CT
James A. Bush - Cheshire CT
Koji Tomita - Tokyo, JP

Assignee:

Bristol-Myers Company - New York NY

International Classification:

A61K 3702

US Classification:

514 12

Abstract:

Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues.

US Patent:

20140115948, May 1, 2014

Filed:

Oct 28, 2013

Appl. No.:

14/064230

Inventors:

James Fred Matson - Pottstown PA, US

International Classification:

A01K 85/14

US Classification:

43 4225, 43 4253

Abstract:

A fishing rig for use in catching fish includes a fly or a lure attached to a hook having an eye, a quadratic surface having first and second ports disposed centrally on the quadratic surface and extending through the surface, and a leader of filament passing first through the first port of the quadratic surface, through the eye of the fly or lure, then through the second port forming a loop upon which the quadratic surface is free to slide to and away from the eye.