James A Metz

US Patent:

7001772, Feb 21, 2006

Filed:

Apr 16, 2002

Appl. No.:

10/124807

Inventors:

Paul G. Roessler - San Diego CA, US
T. Dave Matthews - San Diego CA, US
Tom M. Ramseier - Poway CA, US
James G. Metz - Longmont CO, US

Assignee:

Martek Biosciences Corporation - Columbia MD

International Classification:

C07H 21/04
C12N 15/74
C12N 1/12

US Classification:

435471, 4352572, 4353201, 435232, 536 231, 536 232, 536 237

Abstract:

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.

US Patent:

7851191, Dec 14, 2010

Filed:

Oct 27, 2007

Appl. No.:

11/925885

Inventors:

Paul S. Roessler - San Diego CA, US
T. Dave Matthews - San Diego CA, US
Tom M. Ramseier - Poway CA, US
James G. Metz - Longmont CO, US

Assignee:

Martek Biosciences Corporation - Columbia MD

International Classification:

C12N 9/10
C12N 1/20
C12N 15/74
C12P 21/06
C07H 21/04

US Classification:

435193, 4352523, 435 691, 4353201, 536 232

Abstract:

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.

US Patent:

8206984, Jun 26, 2012

Filed:

Dec 22, 2004

Appl. No.:

11/021712

Inventors:

Paul G. Roessler - San Diego CA, US
T. Dave Matthews - San Diego CA, US
Tom M. Ramseier - Poway CA, US
James G. Metz - Longmont CO, US

Assignee:

Merck Biosciences Corporation - Columbia MD

International Classification:

C12N 15/74
C12N 15/00
C12N 9/10
C12Q 1/68
C12P 21/06
C12P 23/00
C07H 21/04

US Classification:

435471, 435 613, 435 67, 435 691, 435193, 4353201, 4352573, 536 232

Abstract:

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.

US Patent:

20110086390, Apr 14, 2011

Filed:

Nov 9, 2010

Appl. No.:

12/942759

Inventors:

Paul G. ROESSLER - San Diego CA, US
T. Dave Matthews - San Diego CA, US
Tom M. Ramseier - Poway CA, US
James G. Metz - Longmont CO, US

Assignee:

Martek Biosciences Corporation - Columbia MD

International Classification:

C12P 21/02
C12N 15/74

US Classification:

435 691, 435471

Abstract:

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.

US Patent:

20130295607, Nov 7, 2013

Filed:

Jun 21, 2013

Appl. No.:

13/923481

Inventors:

- Heerlen, NL
T. Dave Matthews - San Diego CA, US
Tom M. Ramseier - Poway CA, US
James G. Metz - Longmont CO, US

International Classification:

C12N 15/82

US Classification:

435 691, 435471

Abstract:

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.