James David O'Leary

US Patent:

20110097345, Apr 28, 2011

Filed:

Oct 21, 2010

Appl. No.:

12/909697

Inventors:

John LAMBERT - Cambridge MA, US
James J. O'LEARY - Newton MA, US
Joanne Elizabeth Sarah SCHINDLER - Natick MA, US
Steven WEITMAN - Helotes TX, US
Albert QIN - Winchester MA, US

Assignee:

IMMUNOGEN INC. - Waltham MA

International Classification:

A61K 39/395
A61P 35/00
A61P 35/02

US Classification:

4241781

Abstract:

This invention relates to a method of treatment and dosing regimen for treating disease, such as cancer and mammalian tumors, wherein therapy with a cytotoxic drug is suitable, by the administration of an antibody-toxin conjugate, such as a maytansinoid toxin, by infusion at an initial infusion rate of 1 mg/min or lower on a schedule selected from the group consisting of: (1) an amount of at least about 90 mg/mon day 1 and day 8, every three weeks; (2) at least an amount of about 30 mg/mon day 1, day 2 and day 3, every three weeks; (3) at least an amount of about 45 mg/mon day 1, day 8, and day 15, every 4 weeks; and (4) at least an amount of about 45 mg/mon day 1, day 8 and day 15, every 3 weeks.

US Patent:

53585119, Oct 25, 1994

Filed:

Nov 24, 1992

Appl. No.:

7/981011

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Norwood MA

International Classification:

A61B 1700

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.

US Patent:

57255571, Mar 10, 1998

Filed:

Aug 27, 1996

Appl. No.:

8/703526

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Westwood MA

International Classification:

A61B 1704

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.

US Patent:

62243799, May 1, 2001

Filed:

Oct 2, 1998

Appl. No.:

9/165387

Inventors:

Behrouz Abedian - Lincoln MA
Livia M. Racz - Arlington MA
James P. O'Leary - Medford MA
Philip L. Millstein - Cambridge MA

Assignee:

Trustees of Tufts College - Medford MA

International Classification:

A61C 502

US Classification:

433224

Abstract:

A spinning end of a rotating instrument is used to deform an adhesive material without the adhesive material adhering to the instrument. This process is particularly suited for packing dental composites within oral cavities.

US Patent:

52580156, Nov 2, 1993

Filed:

May 3, 1991

Appl. No.:

7/695536

Inventors:

Lehmann K. Li - Wellesley MA
James P. O'Leary - Medford MA

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

A61B 1700

US Classification:

606232

Abstract:

An improved locking cap for mounting on the smooth flexible filament of a surgical fastener wherein the locking cap is of a thin flat washer-like shape with gripping elements for engaging the filament and locking the cap in position relative to the filament.

US Patent:

51923033, Mar 9, 1993

Filed:

Mar 18, 1992

Appl. No.:

7/853261

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Norwood MA

International Classification:

A61B 1700

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.

US Patent:

50465139, Sep 10, 1991

Filed:

Nov 20, 1989

Appl. No.:

7/439452

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Norwood MA

International Classification:

A61B 1700

US Classification:

128898

Abstract:

A method for anchoring suture to bone, wherein the method comprises the steps of (1) providing a suture anchor of the sort comprising (a) a coupling member, (b) at least one barb, said barb having a first end and a second end and being curved in its normal unstressed state and being capable of being elastically deformed to a substantially straight configuration, said barb being attached to said coupling member so that said second end of said barb is substantially displaced from said coupling member when said barb is in its normal unstressed state but is aligned with said coupling member when said barb is deformed to a substantially straight configuration, and (c) attachment means for attaching the suture to the suture anchor, (2) deforming the barb to a substantially straight configuration and retaining the barb in its deformed condition, and attaching a suture to the suture anchor, and forming a hole in a bone to which the suture is to be anchored, (3) inserting the suture anchor with its deformed barb into the hole in the bone, and (4) releasing the barb from its deformed condition while the suture anchor is disposed in the hole, whereby the barb will restore itself to its normal curved state so as to fix the suture anchor and hence the suture to the bone.

US Patent:

55541712, Sep 10, 1996

Filed:

Oct 24, 1994

Appl. No.:

8/327584

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Westwood MA

International Classification:

A61B 1704

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.