James M Rinker from 3909 N Alabama Ave, Reading, PA 19605, age 60, Phone: 6109211711

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Location:

Reading, Pennsylvania Area

Industry:

Research

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Location:

United States

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Location:

United States

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Location:

United States

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Location:

United States

Peptide Analogs As Irreversible Interleukin-1 Protease Inhibitors
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US Patent:

6576614, Jun 10, 2003
Filed:

Oct 20, 1999
Appl. No.:

09/421954
Inventors:

Roland E. Dolle - King of Prussia PA
Irennegbe K. Osifo - W. Norriton PA
Stanley J. Schmidt - Chester Springs PA
Denton W. Hoyer - Exton PA
Tina Morgan Ross - Audubon PA
Prasad V. Chaturvedula - Cheshire CT
Catherine P. Prouty - Doylestown PA
Mohamed M. A. Awad - Westerly RI
Joseph M. Salvino - Schwenksville PA
James M. Rinker - Hamden CT
Eric P. Lodge - Glendale AZ
Jasbir Singh - Gilbertsville PA
Mark A. Ator - Paoli PA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07K 506
US Classification:

514 19, 514 17, 514 18, 530330, 530331, 562571
Abstract:

Disclosed are compounds, compositions, and methods for inhibiting interleukin-1 protease activity, wherein the compounds are -substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1 converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.

Pyridazines As Interleukin-1 Converting Enzyme Inhibitors
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US Patent:

6624166, Sep 23, 2003
Filed:

Apr 3, 1996
Appl. No.:

08/625680
Inventors:

Roland E. Dolle - King of Prussia PA
Denton W. Hoyer - Exton PA
Tina Morgan Ross - Audubon PA
James M. Rinker - Reading PA
Stanley J. Schmidt - Chester Springs PA
Mark A. Ator - Paoli PA
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D23724
US Classification:

514241, 514247, 51425201, 51425202, 51425203, 51425204, 544238, 544215, 544224
Abstract:

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R is a halogen, or an oxygen linked leaving group including an aromatic ether, an alkyl sulfonate, an aryl sulfonate, an alkyl phosphonate, an aryl phosphonate, an alkyl phosphate or aryl phosphate; R is COOR , C( O)NH(CHR ) âCOOR , NH(CHR ) CON(R )R , C( O)N(R )R or NH(CHR ) OH; R is H or alkyl; R is H, sybstituted or unsubstituted aryl, heteroaryl or alkyl; R and R are independently H, lower alkyl, aryl, hydroxy alkyl, amino alkyl, heteroaryl, lower alkylene-aryl, lower alkylene-heteroaryl or lower cycloalkyl; and m=0-6; pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1 protease activity in a mammal utilizing the compounds and compositions.

Substituted Diphenyloxazoles, The Synthesis Thereof, And The Use Thereof As Fluorescence Probes
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US Patent:

6815445, Nov 9, 2004
Filed:

Oct 9, 2002
Appl. No.:

10/267118
Inventors:

James M. Rinker - Reading PA 19605
International Classification:

A61K 31496
US Classification:

51425402, 514365, 514374, 544369, 548235, 548236, 548201, 5483241
Abstract:

The present invention is directed to a compound of Formula I: wherein A, R , and R are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

4-Pyridazinecarboxamides And Esters As Interleukin-1Β Converting Enzyme Inhibitors
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US Patent:

6995261, Feb 7, 2006
Filed:

Sep 22, 2003
Appl. No.:

10/668475
Inventors:

Roland E. Dolle - King of Prussia PA, US
Denton W. Hoyer - Exton PA, US
Tina Morgan Ross - Audubon PA, US
James M. Rinker - Reading PA, US
Stanley J. Schmidt - Chester Springs PA, US
Mark A. Ator - Paoli PA, US
Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:

C07D 237/24
C07D 401/04
C07F 9/38
A61K 31/501
A61P 19/02
US Classification:

544238, 544114, 544224, 544232, 544239, 544241, 514 85, 5142365, 514247, 51425201, 51425203, 51425204, 51425205
Abstract:

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein.

Quinazolinones
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US Patent:

7060706, Jun 13, 2006
Filed:

Sep 13, 2000
Appl. No.:

10/089167
Inventors:

Werner Mederski - Zwingenberg, DE
Ralf Devant - Darmstadt, DE
Gerhard Barnickel - Darmstadt, DE
Sabine Bernotat-Danielowski - Bad Nauheim, DE
Guido Melzer - Hofheim/Taunus, DE
Bertram Cezanne - Mörfelden-Walldorf, DE
Daljit Dhanoa - Del Mar CA, US
James Rinker - Kenhorst PA, US
Mark Player - Phoenixville PA, US
Richard Soll - Lawrencehill NJ, US
Assignee:

3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:

C07D 239/91
A61K 31/517
A61P 9/10
US Classification:

51426631, 544287
Abstract:

Quinazolinones of formula (I) in which R, R, R, R, R, Y, n and m have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Substituted Diphenyloxazoles, The Synthesis Thereof, And The Use Thereof As Fluorescence Probes
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US Patent:

7078406, Jul 18, 2006
Filed:

Jul 14, 2004
Appl. No.:

10/891259
Inventors:

James M. Rinker - Reading PA, US
Assignee:

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. - Raritan NJ
International Classification:

A61K 31/497
US Classification:

51425402, 514365, 514374, 424 96
Abstract:

The present invention is directed to a compound of Formula I:.