James D Rinker

US Patent:

6576614, Jun 10, 2003

Filed:

Oct 20, 1999

Appl. No.:

09/421954

Inventors:

Roland E. Dolle - King of Prussia PA
Irennegbe K. Osifo - W. Norriton PA
Stanley J. Schmidt - Chester Springs PA
Denton W. Hoyer - Exton PA
Tina Morgan Ross - Audubon PA
Prasad V. Chaturvedula - Cheshire CT
Catherine P. Prouty - Doylestown PA
Mohamed M. A. Awad - Westerly RI
Joseph M. Salvino - Schwenksville PA
James M. Rinker - Hamden CT
Eric P. Lodge - Glendale AZ
Jasbir Singh - Gilbertsville PA
Mark A. Ator - Paoli PA

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07K 506

US Classification:

514 19, 514 17, 514 18, 530330, 530331, 562571

Abstract:

Disclosed are compounds, compositions, and methods for inhibiting interleukin-1 protease activity, wherein the compounds are -substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1 converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.

US Patent:

6624166, Sep 23, 2003

Filed:

Apr 3, 1996

Appl. No.:

08/625680

Inventors:

Roland E. Dolle - King of Prussia PA
Denton W. Hoyer - Exton PA
Tina Morgan Ross - Audubon PA
James M. Rinker - Reading PA
Stanley J. Schmidt - Chester Springs PA
Mark A. Ator - Paoli PA

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D23724

US Classification:

514241, 514247, 51425201, 51425202, 51425203, 51425204, 544238, 544215, 544224

Abstract:

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R is a halogen, or an oxygen linked leaving group including an aromatic ether, an alkyl sulfonate, an aryl sulfonate, an alkyl phosphonate, an aryl phosphonate, an alkyl phosphate or aryl phosphate; R is COOR , C( O)NH(CHR ) âCOOR , NH(CHR ) CON(R )R , C( O)N(R )R or NH(CHR ) OH; R is H or alkyl; R is H, sybstituted or unsubstituted aryl, heteroaryl or alkyl; R and R are independently H, lower alkyl, aryl, hydroxy alkyl, amino alkyl, heteroaryl, lower alkylene-aryl, lower alkylene-heteroaryl or lower cycloalkyl; and m=0-6; pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1 protease activity in a mammal utilizing the compounds and compositions.

US Patent:

6815445, Nov 9, 2004

Filed:

Oct 9, 2002

Appl. No.:

10/267118

Inventors:

James M. Rinker - Reading PA 19605

International Classification:

A61K 31496

US Classification:

51425402, 514365, 514374, 544369, 548235, 548236, 548201, 5483241

Abstract:

The present invention is directed to a compound of Formula I: wherein A, R , and R are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

US Patent:

6995261, Feb 7, 2006

Filed:

Sep 22, 2003

Appl. No.:

10/668475

Inventors:

Roland E. Dolle - King of Prussia PA, US
Denton W. Hoyer - Exton PA, US
Tina Morgan Ross - Audubon PA, US
James M. Rinker - Reading PA, US
Stanley J. Schmidt - Chester Springs PA, US
Mark A. Ator - Paoli PA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 237/24
C07D 401/04
C07F 9/38
A61K 31/501
A61P 19/02

US Classification:

544238, 544114, 544224, 544232, 544239, 544241, 514 85, 5142365, 514247, 51425201, 51425203, 51425204, 51425205

Abstract:

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein.

US Patent:

7078406, Jul 18, 2006

Filed:

Jul 14, 2004

Appl. No.:

10/891259

Inventors:

James M. Rinker - Reading PA, US

Assignee:

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. - Raritan NJ

International Classification:

A61K 31/497

US Classification:

51425402, 514365, 514374, 424 96

Abstract:

The present invention is directed to a compound of Formula I:.

US Patent:

20040009923, Jan 15, 2004

Filed:

Jan 16, 2003

Appl. No.:

10/347641

Inventors:

Roland Dolle - King of Prussia PA, US
Irennegbe Osifo - West Chester PA, US
Stanley Schmidt - Chester Springs PA, US
Denton Hoyer - Exton PA, US
Tina Ross - Audubon PA, US
Prasad Chaturvedula - Exton PA, US
Catherine Prouty - Wayne PA, US
Mohamed Awad - Frazer PA, US
Joseph Salvino - Schwenksville PA, US
James Rinker - Schwenksville PA, US
Eric Lodge - Pottstown PA, US
Jasbir Singh - Gilbertsville PA, US
Mark Ator - Paoli PA, US

International Classification:

A61K038/08
A61K038/06
A61K038/04
C07K005/06
C07K005/04

US Classification:

514/017000, 514/018000, 514/019000, 530/330000, 530/331000

Abstract:

Disclosed are compounds, compositions and methods for inhibiting interleukin-1 protease activity, the compounds having the formula (I).

US Patent:

20080114007, May 15, 2008

Filed:

Oct 19, 2007

Appl. No.:

11/875294

Inventors:

Mark Player - Phoenixville PA, US
William Parsons - Belle Mead NJ, US
Hui Huang - Monroe Twp. NJ, US
Daniel Hutta - Belle Mead NJ, US
Huaping Hu - Pennington NJ, US
James Rinker - Reading PA, US

International Classification:

A61K 31/519
C07D 471/04
C07D 401/02
C07D 401/14
A61P 35/00
A61P 9/00

US Classification:

514264110, 544279000

Abstract:

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, Rand Rare described in the specification.

US Patent:

58345140, Nov 10, 1998

Filed:

Nov 12, 1996

Appl. No.:

8/748117

Inventors:

Roland E. Dolle - King of Prussia PA
James M. Rinker - Reading PA

Assignee:

Vertex Pharmaceuticals, Incorporated - Cambridge MA

International Classification:

A61K 3116

US Classification:

514629

Abstract:

Disclosed are compounds, compositions and methods for inhibiting interleukin-1. beta. protease activity, the compounds having the formula A described herein.