James Paul Saunders

US Patent:

53568796, Oct 18, 1994

Filed:

Feb 14, 1992

Appl. No.:

7/835496

Inventors:

Lee R. Zehner - Brookeville MD
Gilbert V. Levin - Annapolis MD
James P. Saunders - Rockville MD
James R. Beadle - Elkridge MD

Assignee:

Biospherics, Incorporated - Beltsville MD

International Classification:

A61K 3170

US Classification:

514 25

Abstract:

This invention discloses the usefulness of D-tagatose as a treatment for hyperglycemia, diabetes mellitus, and the inhibition of formation of advanced glycosylation end-products associated with the aging process. This invention discloses edible formulations and pharmaceutical compositions containing D-tagatose and the effect of consumption of such formulations on blood level of glucose. D-Tagatose was found to be an anti-hyperglycemic agent. In addition, consumption of D-tagatose in sweetened formulations to inhibit formation of advanced glycosylation end-products in mammals is disclosed. The combination of the anti-hyperglycemic effect and the inhibition of formation of glycosylated proteins and nucleic acids make D-tagatose an ideal agent for alleviating the complications resulting from hyperglycemia, including acceleration of the aging process.

US Patent:

56291833, May 13, 1997

Filed:

Nov 28, 1994

Appl. No.:

8/345869

Inventors:

James A. Saunders - Dayton MD
Benjamin F. Matthews - Laurel MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12N 1509

US Classification:

4351723

Abstract:

Plant germplasm is transformed with foreign DNA by introducing the DNA into pollen grains by a technique such as electroporation, mating ova of the desired plant line with the transformed pollen, and selecting for the transformed germplasm. The germinating pollen, resultant seed, and the progeny can each be screened for expression of the foreign gene. The transformed pollen can be used as a vector for introducing the foreign DNA into plant lines of similar or dissimilar origin, including both monocots and dicots.

US Patent:

54479177, Sep 5, 1995

Filed:

Feb 3, 1994

Appl. No.:

8/190938

Inventors:

Lee R. Zehner - Brookeville MD
Gilbert V. Levin - Annapolis MD
James P. Saunders - Rockville MD
James R. Beadle - Elkridge MD

Assignee:

Biospherics Incorporated - Beltsville MD

International Classification:

A61K 3170

US Classification:

514 23

Abstract:

This invention discloses edible formulations and pharmaceutical compositions containing D-tagatose and the effect of consumption of such formulations on blood level of glucose. D-Tagatose was found to be an anti-hyperglycemic agent. In addition, consumption of D-tagatose in sweetened formulations to inhibit formation of advanced glycosylation end-products in mammals is disclosed. The combination of the anti-hyperglycemic effect and the inhibition of formation of glycosylated proteins and nucleic acids make D-tagatose an ideal agent for alleviating the complications resulting from hyperglycemia, including acceleration of the aging process.