James K Shepard

US Patent:

7531349, May 12, 2009

Filed:

Jan 13, 2004

Appl. No.:

10/756553

Inventors:

James G. Shepard - Palos Verdes Estates CA, US
Kalin Spariosu - Thousand Oaks CA, US

Assignee:

Raytheon Company - Waltham MA

International Classification:

C12M 1/34
C12M 3/00
G01N 21/64
G01J 1/58
A61B 6/02

US Classification:

4352887, 435808, 422 8208, 422 8205, 2504611, 2504621, 2504612, 2504591, 2504831, 378 42, 378 45

Abstract:

A standoff bioagent-detection apparatus and method use a direct ultraviolet source to detect bioagents. In some embodiments, a standoff bioagent-detection apparatus and method use laser-induced fluorescence to determine the presence of a biological agent having an aromatic-protein shell, such as Tryptophan. In some embodiments, multi-wavelength differential laser-induced fluorescence helps reduce false alarm caused by naturally occurring interferants. In some embodiments, a full range of ultraviolet wavelengths is initially simultaneously generated to fluoresce Tryptophan to determine if an ambient level is excessive. When the ambient level is excessive, individual ultraviolet wavelengths may be generated in differential pairs and the detected fluorescence levels may be correlated with atmospheric absorption levels for Tryptophan to determine if a bioagent is highly likely to be present.