James W Sherman

US Patent:

20230114905, Apr 13, 2023

Filed:

Oct 7, 2022

Appl. No.:

18/045036

Inventors:

- Seattle WA, US
James SHERMAN - Kingston WA, US
Vadim LOBANOV - Seattle WA, US
Parag MALLICK - San Mateo CA, US
Ellis ANDERSON - Seattle WA, US

International Classification:

G01N 33/68
C40B 30/04

Abstract:

A method of identifying an extant protein, including (a) providing inputs including: (i) a binding profile, wherein the binding profile includes a plurality of binding outcomes for binding of the extant protein to a plurality of different affinity reagents, wherein individual binding outcomes of the plurality of binding outcomes include a measure of binding between the extant protein and a different affinity reagent of the plurality of different affinity reagents, (ii) a database including information characterizing or identifying a plurality of candidate proteins, and (iii) a binding model; (b) determining a probability for each of the affinity reagents binding to each of the candidate proteins in the database according to the binding model; and (c) identifying the extant protein as a selected candidate protein having a probability for binding each of the affinity reagents that is most compatible with the binding profile for the extant protein.