James W Simon

US Patent:

7371413, May 13, 2008

Filed:

May 5, 2004

Appl. No.:

10/839056

Inventors:

James E. Simon - Princeton NJ, US
Mingfu Wang - Piscataway NJ, US
Kodzo Gbewonyo - Somerset NJ, US
Mohamed M. Rafi - Highland Park NJ, US
Daniel Fahene Acquaye - Accra, GH
Yaw Asianowa - Kumasi, GH

Assignee:

Rutgers, The State University - New Brunswick NJ
BioResources International Inc. - Somerset NJ

International Classification:

A61K 36/00

US Classification:

424725

Abstract:

The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds of Warb. (), commonly known as African nutmeg. These extracts and compounds, namely, butter, butter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation of butter acid extracts are also provided.

US Patent:

8642769, Feb 4, 2014

Filed:

May 3, 2011

Appl. No.:

13/695911

Inventors:

James E. Simon - Princeton NJ, US
Qingli Wu - Annandale NJ, US
Cara Welch - Washington DC, US

International Classification:

C07D 401/00

US Classification:

546196, 514320

Abstract:

This invention provides the methods of separation and identification of a novel type of piperidine flavan alkaloids from an African herbal tea, the leaves of commonly known as kinkeliba, and the procedures for preparing the total piperidine flavan alkaloids (TPFA). In particular, this invention relates to the use of the plant extract that may contain TPFA as anti-diabetic agents in treatment of metabolic disorders and other applications related to this new chemical structure and derivatives thereof.

US Patent:

20060216253, Sep 28, 2006

Filed:

Feb 6, 2006

Appl. No.:

11/347884

Inventors:

Mingfu Wang - Belle Mead NJ, US
James Simon - Princeton NJ, US
Abraham Kim - Morganville NJ, US

Assignee:

Time and Cross, Inc. - North Brunswick NJ

International Classification:

A61K 8/97

US Classification:

424062000, 424769000

Abstract:

The present invention relates to cosmetic products, comprising extracts of , which have a whitening effect. According to the present invention extracting powdered twig with aqueous ethanol provides an extract comprising oxyresveratrol and mulberroside A. Extracts enriched in oxyresveratrol or mulberroside A, as well as purified oxyresveratrol and mulberrocide A may be also be obtained. The extracts or purfied compounds may be added to conventional skin care cosmetics to give whitening cosmetics.

US Patent:

20120135094, May 31, 2012

Filed:

May 14, 2010

Appl. No.:

13/320292

Inventors:

James E. Simon - Princeton NJ, US
Diandian Shen - Somerset NJ, US
Hector Rodolfo Juliani - Highland Park NJ, US
Qingli Wu - Annandale NJ, US

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ

International Classification:

A61K 31/19
A61P 29/00
A61K 36/53
A61K 31/216
A61K 36/534

US Classification:

424745, 514533, 514557, 424747

Abstract:

The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants.

US Patent:

20120136047, May 31, 2012

Filed:

Mar 26, 2010

Appl. No.:

13/260475

Inventors:

James E. Simon - Princeton NJ, US
Wenbin Deng - Davis CA, US

International Classification:

A61K 31/353
C07C 69/353
A61P 25/14
A61P 25/28
A61P 25/00
A61P 25/16
C07D 311/04
A61K 31/225

US Classification:

514456, 549407, 560193, 514548

Abstract:

This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, or synthetic analogs or derivatives thereof, as neuroprotective agents. The methods for preparing the kombo butter or kombo butter acid extracts and the methods for isolating and purifying the active compounds and for preparing their acetylated derivatives are also described.

US Patent:

20130302279, Nov 14, 2013

Filed:

Apr 22, 2013

Appl. No.:

13/868002

Inventors:

James E. Simon - Princeton NJ, US
Qingli Wu - Annandale NJ, US

Assignee:

University of Medicine & Dentistry of New Jersey - Somerset NJ
Rutgers, The State University of New Jersey - New Brunswick NJ

International Classification:

A61K 38/21
A61K 36/53
A61K 36/185
C12N 9/12

US Classification:

424 854, 435184, 424745, 424774, 424778, 424779, 424757, 424755, 42419515

Abstract:

The present invention relates to a novel use of naturally occurring plants, mushroom, extracts thereof that exhibit properties as HCV NS5B polymerase inhibitors.