James Alan Sinclair

US Patent:

7077018, Jul 18, 2006

Filed:

Apr 27, 2004

Appl. No.:

10/833496

Inventors:

James E. Sinclair - Carlsbad CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

B01L 3/02

US Classification:

7386413, 7386332, 7386401, 7386411, 7386414, 7386416, 422 99, 422100

Abstract:

A volume displacement pipette that includes a channel within the piston. The channel allows for cleaning fluids to be continuously run through the pipette tip for cleaning the tip. One end of the channel may be closed during normal operation of the pipette. Multiple pipettes may be combined into an array pipetter.

US Patent:

7169609, Jan 30, 2007

Filed:

Mar 31, 2004

Appl. No.:

10/815176

Inventors:

Paul A. Negulescu - Del Mar CA, US
Alec T. Harootunian - San Diego CA, US
Philip E. Salzmann - Cardiff CA, US
Javier H. Flores - San Diego CA, US
James E. Sinclair - Carlsbad CA, US
Minh Vuong - San Diego CA, US
Ashvani K. Singh - San Diego CA, US
Fred F. VanGoor - San Diego CA, US

Assignee:

Vertex Pharmaceutcals, Inc. - Cambridge MA

International Classification:

C12N 5/00

US Classification:

435395, 4352971, 4352975, 4352884, 2044036

Abstract:

A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber. ”.

US Patent:

7553671, Jun 30, 2009

Filed:

May 25, 2004

Appl. No.:

10/853901

Inventors:

James E. Sinclair - Carlsbad CA, US
Brian Grot - San Diego CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

B01L 9/00

US Classification:

436 45, 436809, 422 72, 422104

Abstract:

Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.

US Patent:

7919047, Apr 5, 2011

Filed:

Jun 5, 2006

Appl. No.:

11/446821

Inventors:

James E. Sinclair - Carlsbad CA, US
Michael P. Emery - Santee CA, US
Minh Vuong - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

B01L 3/02

US Classification:

422100, 7386332

Abstract:

An air displacement pipetter comprises a guidance sleeve positioned within a hole in a cylinder block and a piston within a portion of the guidance sleeve a piston penetrating the cylinder block, a spring energized seal disposed within the cylinder block, a seal capture plate contacting the spring energized seal, a carrier plate, a pipette tip attached to the carrier plate, and a manifold plate between said carrier plate and said cylinder block.

US Patent:

8178055, May 15, 2012

Filed:

May 29, 2009

Appl. No.:

12/475381

Inventors:

James E. Sinclair - Carlsbad CA, US
Brian Grot - San Diego CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 21/75

US Classification:

422400, 422560, 422561, 422565, 422500, 422401, 422562

Abstract:

Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.

US Patent:

8337754, Dec 25, 2012

Filed:

Dec 22, 2009

Appl. No.:

12/644839

Inventors:

Michael P. Emery - Santee CA, US
Matthew C. Wallace - Carlsbad CA, US
James E. Sinclair - Carlsbad CA, US
Raymond J. Gonzales - Chula Vista CA, US
Brian Grot - San Diego CA, US
Sanjay S. Magavi - Cambridge MA, US

Assignee:

Vertex Pharmaceuticals, Incorporated - Cambridge MA

International Classification:

G01N 21/00

US Classification:

422 65, 422 63, 422 64, 422500

Abstract:

Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.

US Patent:

8353969, Jan 15, 2013

Filed:

May 25, 2012

Appl. No.:

13/480747

Inventors:

Jack Barger - Poway CA, US
James Sinclair - Carlsbad CA, US
Michael P. Emery - Santee CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

B01D 9/00

US Classification:

23295R, 23306

Abstract:

Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.

US Patent:

8397592, Mar 19, 2013

Filed:

Feb 19, 2010

Appl. No.:

12/709414

Inventors:

James Sinclair - Carlsbad CA, US
B. Albert Griffin - San Diego CA, US
Minh Vuong - San Diego CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 1/20

US Classification:

7386356, 73 32 R, 7386352

Abstract:

Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.