James Edward Swanson

US Patent:

20220409557, Dec 29, 2022

Filed:

Apr 8, 2022

Appl. No.:

17/716932

Inventors:

James Martin Swanson - Seattle WA, US

International Classification:

A61K 31/137
A61K 9/48
A61K 31/4458
A61K 31/165
A61K 31/407
A61K 31/16
A61K 31/138
A61K 31/4168
A61K 31/5375
A61K 31/55
A61K 31/135

Abstract:

It is proposed that dissipation of relative benefit during long-term treatment is due to long-term tolerance to stimulant medications. To improve adherence and persistence of medication use, it is advantageous to develop medications that are not undermined by long-term tolerance. Disclosed herein in certain implementations are formulations and methods relating to an alternative formulation of medication for the treatment of ADHD based on two principles: (a) retaining the initial immediate-release component of controlled-release formulations that targets a neural mechanism, which elicits acute tolerance, and (b) replacing the subsequent sustained-release component with a medication that maintains the initial benefit by targeting a different neural mechanism does not elicit tolerance, thus allowing more time for acute tolerance elicited by the initial bolus dose of stimulant medication to dissipate completely each day and avoid carry-over and accumulation that results in long-term tolerance.

US Patent:

20190125215, May 2, 2019

Filed:

Oct 30, 2018

Appl. No.:

16/174940

Inventors:

James Martin Swanson - Seattle WA, US
Robert Clay Isenhart - Brooklyn NY, US

International Classification:

A61B 5/107
A61B 5/00

Abstract:

Systems and methods use a three-dimensional snapshot of an infant, child, adolescent, or adult where the subject may have bent legs and an unaligned head position, to provide an estimate of human length. The system identifies anatomical features from the digital information and generates a virtual skeleton. The cumulative distances between pseudo-joints of the virtual skeleton provide an estimate of human length. Comparing length estimates from multiple three-dimensional snapshots of the same individual acquired over time provide an indication of growth of the infant, child, or adolescent. Daily estimates of length can detect growth faltering sooner than less frequent estimates of length, which can lead to timely intervention.