James J Takasugi from 11 Pembroke Ct, Trenton, NJ 08648, age 63, Phone: 6098951090

Uracil Substituted Phenyl Sulfamoyl Carboxamides
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US Patent:

6534492, Mar 18, 2003
Filed:

May 4, 2001
Appl. No.:

09/848881
Inventors:

Marianne Carlsen - Yardley PA
Michael Anthony Guaciaro - Hightstown NJ
James Jan Takasugi - Lawrenceville NJ
Assignee:

BASF Aktiengesellschaft - Ludwigshaften
International Classification:

A61K 3133
US Classification:

514183, 5142272, 514241, 514256, 514269, 514274, 544242, 544309, 544315, 544319, 544335, 544 88, 544 53, 544180, 544182
Abstract:

Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X =H, halogen, C -C -alkyl; X =H, CN, CSâNH , halogen, C -C -alkyl, C -C -haloalkyl; X =H, CN, C -C -alkyl, C -C -alkoxyalkyl, C -C -cycloalkyl, C -C -alkenyl, C -C -alkynyl, optionally substituted benzyl; R , R =H, halogen, optionally substituted hydroxy, C -C -alkyl, C -C -alkenyl, C -C -alkynyl, C -C -cycloalkyl, phenyl, benzyl or C -C -cycloalkenyl, or R +R together with the atom to which they are attached form 3- to 7-membered heterocyclic ring; Q is selected from Q to Q as defined in the description. Use: As herbicides; for the desiccation/defoliation of plants.

Uracil Substituted Phenyl Sulfamoyl Carboxamides
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US Patent:

6689773, Feb 10, 2004
Filed:

Jan 22, 2003
Appl. No.:

10/347920
Inventors:

Marianne Carlsen - Yardley PA
Michael Anthony Guaciaro - Hightstown NJ
James Jan Takasugi - Lawrenceville NJ
Assignee:

BASF Aktiengesellschaft - Ludwigshafen
International Classification:

A61K 3133
US Classification:

514183, 514277, 514385, 514381, 514408, 546 1, 546290, 546329, 548250, 5482622, 5483001
Abstract:

Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X =H, halogen, C -C -alkyl; X =H, CN, CSâNH , halogen, C -C -alkyl, C -C -haloalkyl; X =H, CN, C -C -alkyl, C -C -alkoxyalkyl, C -C -cycloalkyl, C -C -alkenyl, C -C -alkynyl, optionally substituted benzyl; R , R =H, halogen, optionally substituted hydroxy, C -C -alkyl, C -C -alkenyl, C -C -alkynyl, C -C -cycloalkyl, phenyl, benzyl or C -C -cycloalkenyl, or R +R together with the atom to which they are attached form a 3- to 7-membered heterocyclic ring; Q is selected from Q to Q as defined in the description. Use: As herbicides; for the desiccation/defoliation of plants.

Uracil Substituted Phenyl Sulfamoly Carboxamides
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US Patent:

6849618, Feb 1, 2005
Filed:

Oct 15, 2003
Appl. No.:

10/684940
Inventors:

Marianne Carlsen - Yardley PA, US
Michael Anthony Guaciaro - Hightstown NJ, US
James Jan Takasugi - Lawrenceville NJ, US
Assignee:

BASF Aktiengesellschaft - Ludwigshafen
International Classification:

A61K 3133
A61K 31415
A61K 3141
C07D25700
C07D24908
US Classification:

514183, 514277, 514385, 514381, 514408, 546 1, 546290, 546329, 548250, 5482622, 5483001
Abstract:

Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, whereUse: As herbicides; for the desiccation/defoliation of plants.

Acetylamino Benzoic Acid Compounds And Their Use For Nonsense Suppression And The Treatment Of Disease
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US Patent:

7247741, Jul 24, 2007
Filed:

Jan 21, 2005
Appl. No.:

11/048657
Inventors:

Richard G. Wilde - Somerville NJ, US
Ellen M. Welch - Califon NJ, US
James Jan Takasugi - Lawrenceville NJ, US
Neil G. Almstead - Princeton NJ, US
Steven Marc Rubenstein - Pacifica CA, US
Holger Beckmann - Freiburg, DE
Assignee:

PTC Therapeutics, Inc. - South Plainfield NJ
Amgen Inc. - Thousand Oaks CA
International Classification:

C07C 229/00
C07C 205/00
US Classification:

560 19, 562553
Abstract:

Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

Nucleoside Compounds And Their Use For Treating Cancer And Diseases Associated With Somatic Mutations
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US Patent:

7291603, Nov 6, 2007
Filed:

Jul 22, 2003
Appl. No.:

10/625059
Inventors:

Richard G. Wilde - Somerville NJ, US
Paul D. Kennedy - Kalamazoo MI, US
Neil G. Almstead - Holmdel NJ, US
Ellen M. Welch - Califon NJ, US
James J. Takasugi - Lawrenceville NJ, US
Westley J. Friesen - Huntingdon Valley PA, US
Assignee:

PTC Therapeutics, Inc. - South Plainfield NJ
International Classification:

A61K 31/706
US Classification:

514 43, 514 49
Abstract:

The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

Ureido Substituted Benzoic Acid Compounds And Their Use For Nonsense Suppression And The Treatment Of Disease
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US Patent:

7405233, Jul 29, 2008
Filed:

Jan 21, 2005
Appl. No.:

11/048656
Inventors:

Richard G. Wilde - Somerville NJ, US
James J. Takasugi - Lawrenceville NJ, US
Seongwoo Hwang - Edison NJ, US
Ellen M. Welch - Califon NJ, US
Guangming Chen - Bridgewater NJ, US
Assignee:

PTC Therapeutics, Inc. - South Plainfield NJ
International Classification:

A61K 31/415
US Classification:

514386, 514506
Abstract:

The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

Processes For The Preparation Of 1,2,4-Oxadiazole Benzoic Acids
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US Patent:

7678922, Mar 16, 2010
Filed:

Sep 6, 2007
Appl. No.:

11/899813
Inventors:

Neil G. Almstead - Princeton NJ, US
Peter Seongwoo Hwang - Edison NJ, US
Seemon Pines - New Providence NJ, US
Young-Choon Moon - Belle Mead NJ, US
James J. Takasugi - Lawrenceville NJ, US
Assignee:

PTC Therapeutics, Inc. - South Plainfield NJ
International Classification:

C07D 271/06
US Classification:

548131, 548125
Abstract:

Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.

Use Of Acetylamino Benzoic Acid Compounds For Nonsense Suppression And The Treatment Of Disease
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US Patent:

7763656, Jul 27, 2010
Filed:

Apr 24, 2007
Appl. No.:

11/789625
Inventors:

Richard G. Wilde - Somerville NJ, US
Ellen M. Welch - Califon NJ, US
James Jan Takasugi - Lawrenceville NJ, US
Neil G. Almstead - Princeton NJ, US
Steven Marc Rubenstein - Pacifica CA, US
Holger Beckmann - Freiburg, DE
Assignee:

PTC Therapeutics, Inc. - South Plainfield NJ
Amgen Inc. - Thousand Oaks CA
International Classification:

A61K 31/19
US Classification:

514570
Abstract:

Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.