James T Tamura

US Patent:

20200199244, Jun 25, 2020

Filed:

Dec 20, 2019

Appl. No.:

16/723047

Inventors:

- Princeton NJ, US
- Brentford, GB
Suzanne SUCHARD - Portland OR, US
Aaron YAMNIUK - Lawrenceville NJ, US
Stanley KRYSTEK - Ringoes NJ, US
James TAMURA - Yardley PA, US
James BRYSON - Langhorne PA, US
Steven GRANT - Swaffham Prior, GB
Philip DREW - Histon, GB

International Classification:

C07K 16/28
A61K 39/395
A61K 45/06
C07K 16/18

Abstract:

Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single Vor Vdomain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA).