James D Thacker

US Patent:

6344332, Feb 5, 2002

Filed:

Sep 4, 1998

Appl. No.:

09/148491

Inventors:

James Thacker - Manassas VA

Assignee:

Thaco Research, Ltd. - Chantilly VA

International Classification:

C01N 3353

US Classification:

435 71, 435 72, 435 732, 435 79, 435 792, 435 794, 435 4, 435 25, 435 29, 435 31, 435 34, 435968

Abstract:

A method for the rapid detection of actively respiring microorganisms comprises the steps of detecting the presence of microorganisms utilizing microbial enzymatic conversion of tetrazolium salts to formazan products, detecting the presence of formazan product.

US Patent:

7358044, Apr 15, 2008

Filed:

Apr 16, 2004

Appl. No.:

10/825603

Inventors:

James D. Thacker - Marietta OH, US
J. Peter Fuhrer - Dayton OH, US
Kenneth O. Willeford - Starkville MS, US

Assignee:

Argyll Biotechnologies, LLC. - LaJolla CA

International Classification:

C12Q 1/68
A61K 38/17

US Classification:

435 6, 435 691, 530350

Abstract:

A new class of lipopeptides has been surprisingly discovered from mammalian serum that are potent immunoregulators, hereinafter, referred to as Immune Cell Potentiating Factors (“ICPF”s). The clinical and laboratory data show a wide range of prophylactic and therapeutic applications for the ICPFs including primary and adjunctive therapy in the treatment of diseases of both bacterial and viral origin as well as certain neoplastic diseases. Described herein are chemical structures of ICPF of the invention, the likely mode of action, and the surprisingly broad spectrum of therapeutic efficacy and wide margin of safety to the host species.

US Patent:

7608589, Oct 27, 2009

Filed:

Jul 25, 2006

Appl. No.:

11/459772

Inventors:

James D. Thacker - Marietta OH, US

Assignee:

Therimunex Pharmaceuticals, Inc. - Doylestown

International Classification:

A61K 38/00

US Classification:

514 14, 514 12, 514 13, 514 15, 514 16, 514 17

Abstract:

Peptide and peptides that may be covalently linked to a lipid and methods of using such peptides and lipopeptides to prevent or treat disease are disclosed herein.

US Patent:

20020098531, Jul 25, 2002

Filed:

Jan 24, 2002

Appl. No.:

10/053871

Inventors:

James Thacker - Marietta OH, US

International Classification:

C12Q001/70
G01N033/554
G01N033/569

US Classification:

435/007320, 435/005000

Abstract:

The invention relates to kits and methods for the sensitive and rapid typing and enumeration of microorganisms in a sample. The basic method comprises adhering specific capture-antibodies to a solid support, to bind to microorganisms specific for the antibody, and adding primary antibodies specific to a viability marker of the microorganisms. This is followed by the addition of secondary antibodies that may be conjugated to a reporter molecule. Preferably the reporter function involves light and the detectable marker is aequorin and the need for a second antibody is overcome. The invention is useful for the detection of a number of different microorganisms including bacteria, fungi and protozoan of a variety of species.

US Patent:

20020132277, Sep 19, 2002

Filed:

Dec 19, 2001

Appl. No.:

10/020923

Inventors:

James Thacker - Fairfax VA, US

International Classification:

G01N033/554
G01N033/569
C12N001/20

US Classification:

435/007320, 435/252100

Abstract:

The invention relates to methods for the rapid detection, including quantitative detection, of actively respiring microorganisms. One embodiment comprises the steps of amplifying the presence of microorganisms utilizing microbial enzymatic conversion of tetrazolium salts to formazan products, detecting the presence of formazan product utilizing specific antibodies raised to formazans and amplifying the presence of the primary antibody with a secondary antibody conjugated to a detectable marker. Another embodiment of the invention comprises the steps of amplifying the microorganisms utilizing microbial enzymatic conversion of tetrazolium salts to formazan products, capturing digested microbial cell fragments with immobilized primary antibodies specific to the formazans and amplifying the presence of captured cell fragments with reporter antibodies prepared from the primary antibodies conjugated to a detectable marker. Another embodiment of the invention comprises the steps of amplifying microorganisms utilizing microbial enzymatic conversion of tetrazolium salt to formazan products, capturing digested microbial cell fragments on primary antibodies immobilized onto a solid sensor support and detecting the presence of captured cell fragments by the measurement of a change in either the physical, chemical electrical or optical properties of the sensor material.

US Patent:

20110123611, May 26, 2011

Filed:

Apr 24, 2009

Appl. No.:

12/989059

Inventors:

James D. Thacker - Philadelphia PA, US

Assignee:

THERIMUNEX PHARMACEUTICALS, INC. - Doylestown PA

International Classification:

A61K 38/10
C07K 7/00
A61K 9/28
A61K 9/48
A61K 9/12
A61K 9/14
A61K 39/00
A61P 31/00

US Classification:

424456, 530326, 514 214, 424474, 424 45, 424489, 4241851

Abstract:

Peptide and peptides that may be covalently linked to a lipid and methods of using such peptides and lipopeptides to prevent or treat disease are disclosed herein.

US Patent:

20120238491, Sep 20, 2012

Filed:

Apr 8, 2010

Appl. No.:

13/263755

Inventors:

James Douglas Thacker - Doylestown PA, US

Assignee:

THERIMUNEX PHARMACEUTICALS, INC. - Doylestown PA

International Classification:

A61K 38/10
A61P 31/04
A61P 31/12
C07K 17/02
C12N 5/0775

US Classification:

514 24, 530326, 435366, 514 37

Abstract:

The present invention relates to the isolation and structure elucidation of 1-peptidyl-2-arachidonoyl-3-stearoyl glyceride (pDAG) as an active chemical entity in the caprine serum fraction, and the discovery of the innate immune modulating activity of pDAG as an endogenous damage associated molecular pattern

US Patent:

59811960, Nov 9, 1999

Filed:

Sep 9, 1998

Appl. No.:

9/150425

Inventors:

Stanley Stephen Stavinski - Telford PA
Shuguang Wu - North Wales PA
James Douglas Thacker - Manassas VA
Ellen Schalk Casale - Ashburn VA

Assignee:

Rohm and Haas Company - Phila. PA

International Classification:

G01N 3353

US Classification:

435 71

Abstract:

The present invention provides an immunogen, antibodies, kits and methods of using the same to measure diacyl hydrazine compounds. The methods are easy to use, inexpensive and provide suitable cross-activity and sensitivity to enable use under FIFRA guidelines.